Center for Medical Imaging - North East Netherlands (CMI-NEN), University of Groningen, University Medical Center Groningen, PO BOX 30001, NL-9700 RB, Groningen, Netherlands.
Institute of Engineering, Hanze University of Applied Sciences, Groningen, Netherlands.
J Digit Imaging. 2020 Oct;33(5):1301-1305. doi: 10.1007/s10278-020-00375-5. Epub 2020 Aug 10.
The developments in Computed Tomography (CT) and Magnetic Resonance allow visualization of blood flow in vivo using these techniques. However, validation tests are needed to determine a gold standard. For the validation tests, controllable systems that can generate pulsatile flow are needed. In this study, we aimed to develop an affordable pulsatile pump and an artificial circulatory system to simulate the blood flow for validation purposes. Initially, the prerequisites for the phantom were pulsating flow output equal to that of the human cardiac pulse pattern; the flow pattern of the mimicked cardiac output should be equal to that of a human, a variable stroke volume (40-120 ml/beat), and a variable heart rate (60-170 bpm). The developed phantom setup was tested with CT scanner. A washout profile was created based on the image intensity of the selected slice. The test was successful for a heart rate of 70 bpm and a stroke volume of 68 ml, but the system failed to work at various heartbeats and stroke volumes. This was due to the problems with software of the microcontroller. As conclusion in this study, we present a proof of concept for a pulsatile heart phantom pump that can be used in validation tests.
计算机断层扫描（CT）和磁共振技术的发展使得可以使用这些技术对体内血流进行可视化。然而，需要验证测试来确定金标准。对于验证测试，需要能够产生脉动流的可控系统。在这项研究中，我们旨在开发一种经济实惠的脉动泵和人工循环系统，以模拟血流进行验证。最初，幻影的前提条件是脉动流量输出等于人体心脏脉冲模式；模拟心输出量的流动模式应等于人体的流动模式，具有可变的冲程量（40-120ml/beat）和可变的心率（60-170bpm）。开发的幻影设置用 CT 扫描仪进行了测试。根据所选切片的图像强度创建了洗脱曲线。对于 70bpm 的心率和 68ml 的冲程量，测试是成功的，但该系统在不同的心率和冲程量下无法工作。这是由于微控制器软件的问题。在这项研究中，我们提出了一种脉动心脏幻影泵的概念验证，可用于验证测试。
