Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, PR China.
Department of Clinical Pharmacy, Qinghai University Affiliated Hospital, Xining, PR China.
Crit Rev Food Sci Nutr. 2021;61(21):3569-3588. doi: 10.1080/10408398.2020.1803198. Epub 2020 Aug 11.
In recent years, the degradation processes of polysaccharides by human gut microbiota are receiving considerable attention due to the discoveries of the powerful function of gut microbiota. Gut microbiota has developed a sensitive, accurate, and complex system for sensing, capturing, and degrading different polysaccharides. Among the gut microbiota, , a representative species of , is considered as the best degrader of polysaccharides and a potential probiotic in pharmaceutical and food industries. Here, we summarize the degradation system of and the degradation pathways of different polysaccharides by We also describe a technical route for investigating a specific polysaccharide degradation pathway by human gut bacteria. In addition, we also provide the future perspectives in the development of novel polysaccharides or oligosaccharides drugs, precision microbiology medicine, and personalized nutrition.
近年来，由于发现了肠道微生物群的强大功能，人类肠道微生物群对多糖的降解过程受到了相当大的关注。肠道微生物群已经发展出了一种敏感、准确和复杂的系统，用于感知、捕获和降解不同的多糖。在肠道微生物群中，双歧杆菌，一种拟杆菌属的代表性物种，被认为是多糖的最佳降解菌，也是制药和食品工业中一种有潜力的益生菌。在这里，我们总结了双歧杆菌的降解系统以及双歧杆菌对不同多糖的降解途径。我们还描述了一种研究人类肠道细菌特定多糖降解途径的技术路线。此外，我们还提供了在开发新型多糖或寡糖药物、精准微生物医学和个性化营养方面的未来展望。
