Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
J Diabetes Investig. 2020 Sep;11(5):1303-1306. doi: 10.1111/jdi.13368. Epub 2020 Aug 16.
Diabetes is a risk factor for the severity of coronavirus disease 2019 (COVID-19). Little is known how the COVID-19 pandemic has disrupted diabetes-related acute care. We compared hospitalization rates for severe hyperglycemia or hypoglycemia during the COVID-19 outbreak in Hong Kong (study period: 25 January to 24 April 2020) with those during 25 January to 24 April 2019 (inter-year control) and 25 October 2019 to 24 January 2020 (intra-year control), using Poisson regression analysis. Hospitalization rates abruptly decreased after the first confirmed local COVID-19 case on 23 January 2020, by 27% and 23% compared with the inter-year and intra-year control periods, respectively (incidence rate ratio 0.73 and 0.77, P < 0.001). Hospitalizations were reduced for severe hyperglycemia and hypoglycemia, but not diabetic ketoacidosis. This significant reduction in hospitalization rates should alert endocrinologists to take proactive measures to optimize glycemic control of individuals with diabetes.
糖尿病是 2019 年冠状病毒病（COVID-19）严重程度的一个危险因素。目前尚不清楚 COVID-19 大流行如何扰乱了与糖尿病相关的急性护理。我们比较了 2020 年 1 月 25 日至 4 月 24 日香港 COVID-19 爆发期间（研究期间）与 2019 年 1 月 25 日至 4 月 24 日（同期对照）和 2019 年 10 月 25 日至 2020 年 1 月 24 日（年内对照）期间严重高血糖或低血糖住院率，采用泊松回归分析。2020 年 1 月 23 日确诊首例本地 COVID-19 病例后，住院率突然下降，与同期和年内对照相比，分别下降了 27%和 23%（发病率比为 0.73 和 0.77，P<0.001）。严重高血糖和低血糖的住院治疗减少，但糖尿病酮症酸中毒没有减少。住院率的显著下降应提醒内分泌学家采取积极措施，优化糖尿病患者的血糖控制。
