Department of Home Economics Education, College of Education, Chung-Ang University, Seoul, Korea.
Department of Physical Education, College of Education, Chung-Ang University, Seoul, Korea.
J Med Food. 2020 Oct;23(10):1083-1092. doi: 10.1089/jmf.2020.4739. Epub 2020 Aug 11.
Emerging evidence has shown that flavonoids extracted from have beneficial effects on metabolic disorders. However, whether and how jaceosidin ameliorates insulin resistance and diabetic nephropathy in type 2 diabetes mellitus is largely unknown. For 8 weeks, diabetic mice were fed with or without jaceosidin. Oral jaceosidin supplementation reduced fasting blood glucose levels and insulin resistance through the upregulation of insulin receptor downstream pathways in the liver and skeletal muscles. While jaceosidin did not noticeably alter kidney filtration function, this dietary intervention contributed to attenuating the accumulation of advanced glycation end products in diabetic kidneys. The levels of VEGF-a (vascular endothelial growth factor-a) proteins in the diabetic kidneys were markedly diminished by jaceosidin treatments, which increased the expression and activity of Cu (copper) and Zn-SOD (zinc-superoxide dismutase). Therefore, it is suggested that jaceosidin supplementation elicits antidiabetic effects and treats diabetic nephropathy by augmenting insulin signaling, suppressing fibrosis, and enhancing antioxidant activity.
新出现的证据表明，从 中提取的类黄酮对代谢紊乱有有益的影响。然而，在 2 型糖尿病中，虎杖苷是否以及如何改善胰岛素抵抗和糖尿病肾病在很大程度上尚不清楚。在 8 周的时间里，给 糖尿病小鼠喂食或不喂食虎杖苷。口服虎杖苷补充剂通过上调肝脏和骨骼肌中胰岛素受体下游途径来降低空腹血糖水平和胰岛素抵抗。虽然虎杖苷对肾脏滤过功能没有明显改变，但这种饮食干预有助于减轻糖尿病肾脏中晚期糖基化终产物的积累。虎杖苷处理显著降低了糖尿病肾脏中 VEGF-a（血管内皮生长因子-a）蛋白的水平，增加了 Cu（铜）和 Zn-SOD（锌-超氧化物歧化酶）的表达和活性。因此，建议虎杖苷补充剂通过增强胰岛素信号、抑制纤维化和增强抗氧化活性来发挥抗糖尿病作用并治疗糖尿病肾病。
