Lee Hyemi, Zhao Xiangyu, Son Young-Ok, Yang Siyoung
Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Korea.
Department of Pharmacology, Ajou University School of Medicine, Suwon 16499, Korea.
Pharmaceuticals (Basel). 2021 Feb 6;14(2):131. doi: 10.3390/ph14020131.
Osteoarthritis (OA) is an age-related degenerative disease for which an effective disease-modifying therapy is not available. Natural compounds derived from plants have been traditionally used in the clinic to treat OA. Over the years, many studies have explored the treatment of OA using natural extracts. Although various active natural extracts with broad application prospects have been discovered, single compounds are more important for clinical trials than total natural extracts. Moreover, although natural extracts exhibit minimal safety issues, the cytotoxicity and function of all single compounds in a total extract remain unclear. Therefore, understanding single compounds with the ability to inhibit catabolic factor expression is essential for developing therapeutic agents for OA. This review describes effective single compounds recently obtained from natural extracts and the possibility of developing therapeutic agents against OA using these compounds.
骨关节炎（OA）是一种与年龄相关的退行性疾病，目前尚无有效的改善病情的治疗方法。传统上，从植物中提取的天然化合物已被用于临床治疗OA。多年来，许多研究探索了使用天然提取物治疗OA。尽管已经发现了各种具有广泛应用前景的活性天然提取物，但对于临床试验而言，单一化合物比天然提取物整体更为重要。此外，尽管天然提取物的安全性问题极小，但提取物中所有单一化合物的细胞毒性和功能仍不清楚。因此，了解具有抑制分解代谢因子表达能力的单一化合物对于开发OA治疗药物至关重要。本综述描述了最近从天然提取物中获得的有效单一化合物，以及使用这些化合物开发抗OA治疗药物的可能性。
