Research Center of Molecular Exercise Science, University of Physical Education, Budapest 1123, Hungary.
Faculty of Health and Sports Science, Doshisha University, Kyotanabe 610-0394, Japan.
J Sport Health Sci. 2020 Sep;9(5):405-414. doi: 10.1016/j.jshs.2020.03.004. Epub 2020 Mar 19.
MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.
MicroRNAs (miRs) 是一种小的调节性 RNA 转录物，能够通过进入一种称为 RNA 诱导沉默复合物的细胞双分子装置，对 mRNA 信息进行转录后沉默。miRs 参与细胞过程的调节，产生、消除或修复活性氧引起的损伤，并且是氧化还原平衡的活跃参与者。线粒体生物发生、功能增加和骨骼肌肥大是对常规运动的重要适应性反应。在本综述中，我们强调了 miR 的一些氧化还原敏感的调节作用。
