炎症性肠病易感性受 IL-8、IL-10 和 IL-18 多态性影响：一项荟萃分析。
Predisposition of Inflammatory Bowel Disease Is Influenced by IL-8, IL-10, and IL-18 Polymorphisms: A Meta-Analysis.
机构信息
Department of Gastrointestinal and Colorectal Surgery, China-Japan Union Hospital of Jilin University, Jilin, China.
Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Jilin, China,
出版信息
Int Arch Allergy Immunol. 2020;181(10):799-806. doi: 10.1159/000509110. Epub 2020 Aug 11.
BACKGROUND
Whether interleukin (IL)-8, IL-10, and IL-18 polymorphisms influence predisposition of inflammatory bowel disease (IBD) remains uncertain.
OBJECTIVES
The authors conducted a meta-analysis to explore relationships between IL-8, IL-10, or IL-18 polymorphisms and predisposition of IBD by merging the results of eligible literatures.
METHODS
A thorough literature search in MEDLINE, Embase, Wanfang, VIP, and CNKI was conducted by the authors to identify eligible literatures, and 33 literatures were finally selected for merged analyses.
RESULTS
We found that genotypic frequencies of IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872, and IL-10 rs1800896 polymorphisms among cases with IBD and population-based controls differed significantly. Moreover, we found that genotypic frequencies of IL-8 rs4073, IL-10 rs1800871, and IL-18 rs1946518 polymorphisms among cases with IBD and population-based controls of Asian origin differed significantly, whereas genotypic frequency of IL-10 rs1800896 polymorphism among cases with IBD and population-based controls of Caucasian origin also differed significantly. Furthermore, genotypic frequency of IL-18 rs187238 polymorphism among cases with Crohn's disease (CD) and population-based controls also differed significantly.
CONCLUSIONS
The present meta-analysis shows that IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872, IL-10 rs1800896, and IL-18 rs1946518 polymorphisms may influence predisposition of IBD. Furthermore, IL-18 rs187238 polymorphism may influence predisposition of CD, but not predisposition of ulcerative colitis.
背景
白细胞介素（IL）-8、IL-10 和 IL-18 多态性是否影响炎症性肠病（IBD）的易感性仍不确定。
目的
作者通过合并合格文献的结果，进行荟萃分析以探讨 IL-8、IL-10 或 IL-18 多态性与 IBD 易感性之间的关系。
方法
作者在 MEDLINE、Embase、万方、VIP 和 CNKI 中进行了全面的文献检索，以确定合格的文献，最终选择了 33 篇文献进行合并分析。
结果
我们发现，IBD 患者和基于人群的对照之间的 IL-8 rs4073、IL-10 rs1800871、IL-10 rs1800872 和 IL-10 rs1800896 基因型频率存在显著差异。此外，我们发现，IBD 患者和基于人群的亚洲对照之间的 IL-8 rs4073、IL-10 rs1800871 和 IL-18 rs1946518 基因型频率存在显著差异，而 IBD 患者和基于人群的高加索对照之间的 IL-10 rs1800896 基因型频率也存在显著差异。此外，克罗恩病（CD）患者和基于人群的对照之间的 IL-18 rs187238 基因型频率也存在显著差异。
结论
本荟萃分析表明，IL-8 rs4073、IL-10 rs1800871、IL-10 rs1800872、IL-10 rs1800896 和 IL-18 rs1946518 多态性可能影响 IBD 的易感性。此外，IL-18 rs187238 多态性可能影响 CD 的易感性，但不影响溃疡性结肠炎的易感性。
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