Department of Oncology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
IUBMB Life. 2020 May;72(5):957-964. doi: 10.1002/iub.2228. Epub 2020 Feb 20.
Interleukin polymorphisms might influence predisposition to lung cancer (LC), but the results of already published studies regarding the relationship between interleukin polymorphisms and LC were still controversial and ambiguous. So the authors designed this meta-analysis to more precisely estimate relationship between interleukin polymorphisms and LC by pooling the results of already published related studies. The authors searched Pubmed, Embase, Web of Science, and CNKI for already published studies. Thirty-five already published studies were pooled and analyzed in this meta-analysis. The pooled meta-analyses results showed that distributions of IL-4 rs2243250 polymorphism among patients and controls from Asian countries differed significantly (dominant comparison: OR = 1.29, 95% CI 1.07-1.55; overdominant comparison: OR = 0.83, 95% CI 0.73-0.95; allele comparison: OR = 1.26, 95% CI 1.03-1.54), and distributions of IL-10 rs1800872 polymorphism among patients and controls from Caucasian countries also differed significantly (recessive comparison: OR = 0.54, 95% CI 0.35-0.83; overdominant comparison: OR = 1.26, 95% CI 1.05.1.51). No genotypic distribution differences were observed for IL-4 rs2070874, IL-6 rs1800795, IL-6 rs1800796, IL-8 rs4073, IL-10 rs1800871, and IL-10 rs1800896 polymorphisms in pooled meta-analyses. This meta-analysis suggested that IL-4 rs2243250 might influence predisposition to LC in Asians, whereas IL-10 rs1800872 polymorphism might influence predisposition to LC in Caucasians.
白细胞介素多态性可能影响肺癌（LC）的易感性，但已发表的研究结果表明白细胞介素多态性与 LC 之间的关系仍存在争议和不明确。因此，作者设计了这项荟萃分析，通过汇集已发表的相关研究结果，更准确地估计白细胞介素多态性与 LC 之间的关系。作者检索了 Pubmed、Embase、Web of Science 和 CNKI 以获取已发表的研究。这项荟萃分析共纳入了 35 项已发表的研究。荟萃分析结果显示，亚洲人群中 IL-4 rs2243250 多态性在病例组和对照组中的分布存在显著差异（显性比较：OR=1.29，95%CI 1.07-1.55；超显性比较：OR=0.83，95%CI 0.73-0.95；等位基因比较：OR=1.26，95%CI 1.03-1.54），白种人群中 IL-10 rs1800872 多态性在病例组和对照组中的分布也存在显著差异（隐性比较：OR=0.54，95%CI 0.35-0.83；超显性比较：OR=1.26，95%CI 1.05-1.51）。在荟萃分析中，未观察到 IL-4 rs2070874、IL-6 rs1800795、IL-6 rs1800796、IL-8 rs4073、IL-10 rs1800871 和 IL-10 rs1800896 多态性的基因型分布差异。这项荟萃分析表明，IL-4 rs2243250 可能影响亚洲人群 LC 的易感性，而 IL-10 rs1800872 多态性可能影响白种人群 LC 的易感性。
