Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, 59078-970, Brazil.
Collaborative Researcher in Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000-Lagoa Nova, Natal, CEP 59078970, Brazil.
Syst Rev. 2020 Aug 11;9(1):176. doi: 10.1186/s13643-020-01433-3.
Vitamin D deficiency can play a role in extraskeletal functions that are involved with a set of risk factors associated with metabolic syndrome (MetS). The purpose of this review is to investigate the impact of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with MetS.
EMBASE, Medline, Web of Science, Lilacs, the Cochrane Central Register of Controlled Trials, clinicaltrials.gov databases, and grey literature will be systematically searched for randomized controlled trials (RCTs) of vitamin D supplementation compared with placebo, through December 2020. We will include in the study patients with MetS diagnosed by the criteria set forth by the National Cholesterol Education Program Adult Treatment Panel III or the International Diabetes Federation. The effect of oral vitamin D supplementation on lipid profile improvement (triglycerides, high-density lipoprotein cholesterol-HDL-C) is this review's primary outcome. The systematic review will be performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The study screening, data extraction, and quality assessment will be fulfilled by two independent reviewers according to the Cochrane Risk of Bias tool (RoB 2.0). The results of the systematic review will be provided according to the type of intervention, characteristics of the target population, the methods of measurement of vitamin D, the calculated vitamin D concentrations, types of biological samples, and types of outcomes. Meta-analyses will be conducted where appropriate. The Cochran's Q test and the I-heterogeneity test will be used to assess the presence of heterogeneity and whether the fixed or the random-effects model would be appropriate for combining study results using the inverse variance method or the DerSimonian-Lair method, respectively. Publication bias will be evaluated using funnel plots and Egger's and Begg's tests. The strength of the evidence will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).
This systematic review will assess the effects of vitamin D supplementation on fasting glucose and triglyceride levels, waist circumference and mean blood pressure, and HDL-C among individuals with MetS. These findings may assist with decision-making within a clinical setting.
PROSPERO registration number CRD42019123212.
维生素 D 缺乏症可能在骨骼外功能中发挥作用，这些功能与一组与代谢综合征（MetS）相关的危险因素有关。本综述的目的是研究维生素 D 补充对 MetS 患者空腹血糖、血脂异常、血压和腹型肥胖的影响。
我们将系统地检索 EMBASE、Medline、Web of Science、Lilacs、Cochrane 对照试验中心注册库、clinicaltrials.gov 数据库和灰色文献，以获取截至 2020 年 12 月的维生素 D 补充与安慰剂相比的随机对照试验（RCT）。我们将纳入按照美国国家胆固醇教育计划成人治疗专家组 III 或国际糖尿病联合会标准诊断为 MetS 的患者。本综述的主要结局是口服维生素 D 补充对血脂谱改善（甘油三酯、高密度脂蛋白胆固醇-HDL-C）的影响。该系统评价将遵循系统评价和荟萃分析的首选报告项目（PRISMA）指南进行。研究筛选、数据提取和质量评估将由两名独立评审员根据 Cochrane 偏倚风险工具（RoB 2.0）进行。系统评价的结果将根据干预类型、目标人群特征、维生素 D 测量方法、计算的维生素 D 浓度、生物样本类型和结局类型提供。在适当的情况下将进行荟萃分析。Cochran's Q 检验和 I 异质性检验将用于评估是否存在异质性，以及使用Inverse variance 法或 DerSimonian-Lair 法，固定效应模型还是随机效应模型更适合组合研究结果。漏斗图和 Egger's 和 Begg's 检验将用于评估发表偏倚。证据的强度将根据推荐评估、制定和评估（GRADE）的分级进行评估。
本系统评价将评估维生素 D 补充对 MetS 个体空腹血糖和甘油三酯水平、腰围和平均血压以及高密度脂蛋白胆固醇的影响。这些发现可能有助于在临床环境中做出决策。
PROSPERO 注册号 CRD42019123212。
