恶性疟原虫肌动蛋白基因的核苷酸序列及推导的氨基酸序列。

Nucleotide sequence and deduced amino acid sequence of a Plasmodium falciparum actin gene.

作者信息

Wesseling J G, de Ree J M, Ponnudurai T, Smits M A, Schoenmakers J G

机构信息

Department of Molecular Biology Faculty of Science, University of Nijmegen, The Netherlands.

出版信息

Mol Biochem Parasitol. 1988 Jan 15;27(2-3):313-20. doi: 10.1016/0166-6851(88)90051-5.

DOI:10.1016/0166-6851(88)90051-5

PMID:3278231

Abstract

The nucleotide sequence of a Plasmodium falciparum actin gene has been established. The gene codes for a protein of 376 amino acids and is not interrupted by introns. The nucleotide sequence reveals an extreme bias in codon usage. Not less than 85% of the codons possess an A or T at the third position. As has been found for the actins in other unicellular eukaryotes, P. falciparum actin is related both to vertebrate cytoplasmic and vertebrate muscle specific actins. However, the malarial actin is one of the most alpha-like actins hitherto found in lower eukaryotes.

摘要

恶性疟原虫肌动蛋白基因的核苷酸序列已确定。该基因编码一种由376个氨基酸组成的蛋白质，且无内含子打断。核苷酸序列显示出密码子使用上的极端偏向性。不少于85%的密码子在第三位含有A或T。正如在其他单细胞真核生物的肌动蛋白中所发现的那样，恶性疟原虫肌动蛋白与脊椎动物细胞质肌动蛋白和脊椎动物肌肉特异性肌动蛋白都有关联。然而，疟原虫肌动蛋白是迄今在低等真核生物中发现的最类似α-肌动蛋白的肌动蛋白之一。