Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Cell Biol Int. 2020 Sep;44(9):1792-1797. doi: 10.1002/cbin.11403. Epub 2020 Jun 3.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is uncontrollably spread all over the world. The host immune responses strongly try to confront it with all the potential cells and cytokines. With chronically condition of SARS-CoV-2, natural killer cells and T cells become exhausted and decreasing their count leads to lymphopenia. Inability to eradicate the infected organ makes hyperinitiation of the immune system, which releases the excessive inflammatory cytokines to compensate the exhausted one as well as the low lymphocytes counts; it consequently leads to the cytokine storm syndrome. These mechanisms and the potential therapeutic targeting are discussed in this paper.
严重急性呼吸系统综合症冠状病毒 2 型（SARS-CoV-2）在全球范围内失控传播。宿主的免疫反应会极力调动所有潜在的细胞和细胞因子与之对抗。在 SARS-CoV-2 慢性感染的情况下，自然杀伤细胞和 T 细胞耗竭，数量减少导致淋巴细胞减少症。由于无法清除受感染的器官，免疫系统过度启动，释放过多的炎症细胞因子来弥补耗竭的细胞因子和低淋巴细胞计数；从而导致细胞因子风暴综合征。本文讨论了这些机制和潜在的治疗靶点。
