Ahmed Irshad, Eltaweel Nashwa, Antoun Lina, Rehal Anoop
Obstetrics and Gynaecology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
Obstetrics and Gynaecology, Birmingham Heartlands Hospital, Birmingham, West Midlands, UK.
BMJ Case Rep. 2020 Aug 11;13(8):e237521. doi: 10.1136/bcr-2020-237521.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has presented many diagnostic challenges and uncertainties. Little is known about common pathologies complicating pregnancy and how their behaviour is modified by the presence of SARS-CoV-2. Pregnancy itself can alter the body's response to viral infection, which can cause more severe symptoms. We report the first case of a patient affected with sudden-onset severe pre-eclampsia complicated by acute fatty liver disease of pregnancy, HELLP (haemolysis, elevated liver enzymes and low platelet) syndrome and acute kidney injury following SARS-CoV-2 infection. Although an initial diagnostic dilemma, a multidisciplinary team approach was required to ensure a favourable outcome for both the mother and the baby. Our case report highlights the need for health professionals caring for pregnant women to be aware of the complex interplay between SARS-CoV-2 infection and hypertensive disorders of pregnancy.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行带来了许多诊断方面的挑战和不确定性。对于妊娠合并的常见病理情况以及SARS-CoV-2的存在如何改变其表现，我们知之甚少。妊娠本身会改变身体对病毒感染的反应，这可能导致更严重的症状。我们报告了首例感染SARS-CoV-2后突发严重先兆子痫并伴有妊娠急性脂肪肝、HELLP（溶血、肝酶升高和血小板减少）综合征及急性肾损伤的患者。尽管最初存在诊断难题，但需要多学科团队协作以确保母婴均获得良好结局。我们的病例报告强调，照顾孕妇的医护人员有必要了解SARS-CoV-2感染与妊娠高血压疾病之间复杂的相互作用。
