Chopra Seema, Syal Arshi, Arya Yajur
Department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Internal Medicine, Government Medical College and Hospital, Chandigarh, India.
Tzu Chi Med J. 2021 May 11;34(1):29-34. doi: 10.4103/tcmj.tcmj_290_20. eCollection 2022 Jan-Mar.
The clinical manifestations of COVID-19 are diverse with the involvement of different organ systems. Renal involvement is particularly noteworthy with acute kidney injury (AKI) being an important disease manifestation, particularly in pregnancy. Pregnancy itself serves as a high-risk condition for COVID-19 disease and a risk factor for deterioration, developing a more severe illness than nonpregnant women, and subsequent higher intensive care unit admission, oxygen therapy, and ventilatory support. There are reports in the literature highlighting the involvement of vital organs in pregnancy; however, data pertaining to AKI in pregnancy during COVID-19 are lacking in terms of risk factors, disease management, and outcomes. The entire spectrum of hormonal changes and adaptive mechanisms in pregnancy can be adversely affected by this viral infection. A literature search regarding AKI in COVID-19 in pregnancy was performed on PubMed, Scopus, Google Scholar, and ScienceDirect, and the relevant articles were selected. Our review highlights key issues pertaining to AKI in COVID-19 in pregnancy in an attempt to overcome, albeit partly, the scarcity of corroborative literature regarding the same.
新型冠状病毒肺炎（COVID-19）的临床表现多样，可累及不同器官系统。肾脏受累尤其值得关注，急性肾损伤（AKI）是一种重要的疾病表现，在妊娠期尤为如此。妊娠本身就是COVID-19疾病的高危因素，也是病情恶化的危险因素，孕妇比非孕妇更容易发展为重症疾病，随后入住重症监护病房、接受氧疗和通气支持的比例更高。文献中有报道强调了妊娠期重要器官的受累情况；然而，关于COVID-19期间妊娠期AKI的危险因素、疾病管理和结局的数据尚缺乏。妊娠期间的整个激素变化和适应性机制都可能受到这种病毒感染的不利影响。我们在PubMed、Scopus、谷歌学术和ScienceDirect上对妊娠期COVID-19相关的AKI进行了文献检索，并筛选了相关文章。我们的综述强调了妊娠期COVID-19相关AKI的关键问题，试图部分克服关于该主题的确证文献稀缺的问题。
