Li Cheng, Zheng Xianchuang, Chen Weizhi, Ji Shilu, Yuan Yang, Jiang Xiqun
Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210023, China.
Institute of Nanophotonics, Jinan University, Guangzhou 511443, China.
Nano Lett. 2020 Sep 9;20(9):6526-6534. doi: 10.1021/acs.nanolett.0c02272. Epub 2020 Aug 10.
The efficiency of photodynamic therapy (PDT) highly depends on the tumor oxygenation state. However, PDT itself can not only cause oxygen depletion but also prevent oxygen supply in tumors. Such self-confinement effect significantly limits the efficacy of PDT, especially fractionated PDT (fPDT). Herein, we proposed a multifunctional nanoparticle system having a four-pronged pipelined therapeutic scheme to address this issue. It performed oxygen supply and tumor microenvironment modulation together to effectively maintain tumor oxygenation even after multiple PDT fractions. It also introduced a new photosensitizer that not only was highly efficient in producing ROS but also could visually report tumor oxygenation state in a real-time fashion. All these functions were integrated into a single nanoparticulate system to obtain pipeline-style teamwork, which was then applied for the fPDT on a mice tumor model, and achieved significantly better tumor oxygenation even after multiple PDT fractions, ending up with a better tumor inhibition efficiency.
光动力疗法（PDT）的效率高度依赖于肿瘤的氧合状态。然而，PDT本身不仅会导致氧耗竭，还会阻碍肿瘤中的氧气供应。这种自我限制效应显著限制了PDT的疗效，尤其是分次光动力疗法（fPDT）。在此，我们提出了一种具有四管齐下治疗方案的多功能纳米颗粒系统来解决这一问题。它同时进行氧气供应和肿瘤微环境调节，即使在多次PDT分次治疗后也能有效维持肿瘤氧合。它还引入了一种新的光敏剂，不仅能高效产生活性氧，还能实时直观地报告肿瘤氧合状态。所有这些功能都集成到一个单一的纳米颗粒系统中，以实现流水线式的协同作用，然后将其应用于小鼠肿瘤模型的fPDT，即使在多次PDT分次治疗后也能实现显著更好的肿瘤氧合，最终获得更好的肿瘤抑制效率。
