Department of Medical Imaging, Guizhou Provincial People's Hospital, Guiyang, China.
School of Basic Medicine, Guizhou Medical University, Guiyang, China.
Ann Palliat Med. 2021 May;10(5):5808-5812. doi: 10.21037/apm-20-576. Epub 2020 Aug 10.
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly, which now has turned into a pandemic. The new emerging infectious disease has raised many challenges and uncertainties regarding disease management and prognosis in immunocompromised patient populations. The risk of COVID-19 among people living with human immunodeficiency virus (HIV) has different opinions. Some scholars speculated that patients with HIV may be at decreased risk for complications of COVID-19 because HIV antiretroviral medications may have activity against coronaviruses such as SARS-CoV-2. But others have the opposite because of the immunosuppression for HIV patients. Here we reported a case of HIV-infected patient confirmed with COVID-19 and had a favourable prognosis. The patient was a 24-year-old male who was diagnosed with HIV infection 2 years ago and then followed a regular antiretroviral therapy (ART). After infected with COVID-19, the patient had no other clinical symptoms and laboratory abnormalities throughout the course of the disease except presented with fever for a short-term (2 days), and no secondary infection or exacerbation occurred after admission in hospital. Follow-up chest CT showed that the lung lesions disappeared within a short period of time. After standard treatment by 9 days, the patient was cured and discharged. This report highlights the importance of ART for HIV-infected persons, and with regular ART for HIV patients may reduce adverse consequences after infection with COVID-19.
新型冠状病毒病(COVID-19)是由严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)引起的一种快速传播的疾病,现已成为一种大流行病。这种新出现的传染病给免疫功能低下患者人群的疾病管理和预后带来了许多挑战和不确定性。HIV 感染者患 COVID-19 的风险存在不同意见。一些学者推测,HIV 患者可能因 HIV 抗病毒药物对 SARS-CoV-2 等冠状病毒具有活性而患 COVID-19 并发症的风险降低。但也有人认为 HIV 患者由于免疫抑制而风险更高。在此,我们报告了一例确诊 COVID-19 的 HIV 感染患者,该患者预后良好。患者为 24 岁男性,2 年前被诊断为 HIV 感染,随后接受了常规抗逆转录病毒治疗(ART)。感染 COVID-19 后,患者除了短期发热(2 天)外,无其他临床症状和实验室异常,住院后也未发生二次感染或恶化。随访胸部 CT 显示肺部病变在短时间内消失。经过 9 天的标准治疗后,患者痊愈出院。本报告强调了 ART 对 HIV 感染者的重要性,HIV 患者定期接受 ART 治疗可能会降低感染 COVID-19 后的不良后果。