Rothzerg Emel, Ho Xuan D, Xu Jiake, Wood David, Märtson Aare, Maasalu Katre, Kõks Sulev
School of Biomedical Sciences, The University of Western Australia, Perth, WA 6009, Australia.
Perron Institute for Neurological and Translational Science, QEII Medical Centre, Nedlands, WA 6009, Australia.
Exp Biol Med (Maywood). 2020 Oct;245(16):1437-1443. doi: 10.1177/1535370220949139. Epub 2020 Aug 12.
Osteosarcoma (OS, also known as osteogenic sarcoma) is the most common primary malignancy of bone in children and adolescents. The molecular mechanisms of OS are extremely complicated and its molecular mediators remain to be elucidated. We sequenced total RNA from 18 OS bone samples (paired normal-tumor biopsies). We found statistically significant (FDR <0.05) 26 differentially expressed transcript variants of gene with different expressions in normal and tumor samples. These findings contribute to the understanding of molecular mechanisms of OS development and provide encouragement to pursue further research.
骨肉瘤（OS，也称为成骨肉瘤）是儿童和青少年中最常见的原发性骨恶性肿瘤。骨肉瘤的分子机制极其复杂，其分子介质仍有待阐明。我们对18份骨肉瘤骨样本（配对的正常肿瘤活检样本）的总RNA进行了测序。我们发现，在正常样本和肿瘤样本中，有26个基因的转录变体表达存在差异，具有统计学意义（FDR<0.05）。这些发现有助于理解骨肉瘤发生发展的分子机制，并为进一步研究提供了动力。
