Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, China.
Department of Pathology, First Affiliated Hospital, Dalian Medical University, Dalian 116044, China.
J Mol Cell Biol. 2019 Oct 25;11(10):920-929. doi: 10.1093/jmcb/mjz033.
Alternative splicing is critical for human gene expression regulation, which plays a determined role in expanding the diversity of functional proteins. Importantly, alternative splicing is a hallmark of cancer and a potential target for cancer therapeutics. Based on the statistical data, breast cancer is one of the top leading causes of cancer-related deaths in women worldwide. Strikingly, alternative splicing is closely associated with breast cancer development. Here, we seek to provide a general review of the relationship between alternative splicing and breast cancer. We introduce the process of alternative splicing and its regulatory role in cancers. In addition, we highlight the functions of aberrant alternative splicing and mutations of splicing factors in breast cancer progression. Moreover, we discuss the role of alternative splicing in cancer drug resistance and the potential of being targets for cancer therapeutics.
选择性剪接对于人类基因表达调控至关重要，它在扩展功能蛋白多样性方面起着决定性作用。重要的是，选择性剪接是癌症的一个标志，也是癌症治疗的一个潜在靶点。根据统计数据，乳腺癌是全球女性癌症相关死亡的主要原因之一。惊人的是，选择性剪接与乳腺癌的发展密切相关。在这里，我们试图对选择性剪接与乳腺癌之间的关系进行综述。我们介绍了选择性剪接的过程及其在癌症中的调控作用。此外，我们强调了异常选择性剪接和剪接因子突变在乳腺癌进展中的作用。此外，我们还讨论了选择性剪接在癌症耐药中的作用以及作为癌症治疗靶点的潜力。
