Katsurahara Keita, Shiozaki Atsushi, Fujiwara Hitoshi, Konishi Hirotaka, Kudou Michihiro, Shoda Katsutoshi, Arita Tomohiro, Kosuga Toshiyuki, Morimura Ryo, Murayama Yasutoshi, Kuriu Yoshiaki, Ikoma Hisashi, Kubota Takeshi, Nakanishi Masayoshi, Okamoto Kazuma, Otsuji Eigo
Division of Digestive Surgery, Department of Surgery, University Hospital, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Oncol Lett. 2020 Oct;20(4):40. doi: 10.3892/ol.2020.11901. Epub 2020 Jul 23.
Cervical esophageal squamous cell carcinoma (CESCC) is less common compared with thoracic esophageal cancer, and few studies have investigated the clinicopathological features of CESCC. The present study analyzed 69 patients with CESCC who underwent various therapies at the University Hospital of Kyoto Prefectural University of Medicine between January 2000 and December 2016. The distance between the inferior border of the cricoid cartilage and upper edge of the tumor was evaluated using positron emission tomography and computed tomography. Positive and negative values indicated oral and anal directions, respectively. Using receiver operating characteristic curves, the cut-off value for laryngeal preservation was calculated as -5 mm. According to this value, the patients were divided into two groups: The short group (distance from the cricoid cartilage ≥-5 mm) and long group (distance from the cricoid cartilage <-5 mm). There were no significant differences in clinicopathological factors between the two groups except for body mass index. In univariate analysis, the 3-year overall survival rate was significantly lower in short group (45.4 vs. 79.6%; P=0.009). In multivariate analysis, short group was an independent prognostic risk factor (hazard ratio=2.65; P=0.039). This may be due to lymphatic flow around the cervical esophagus.
与胸段食管癌相比，颈段食管鳞状细胞癌（CESCC）较为少见，且很少有研究对CESCC的临床病理特征进行调查。本研究分析了2000年1月至2016年12月期间在京都府立医科大学附属医院接受各种治疗的69例CESCC患者。使用正电子发射断层扫描和计算机断层扫描评估环状软骨下缘与肿瘤上缘之间的距离。正值和负值分别表示口侧和肛侧方向。使用受试者工作特征曲线，计算出保留喉的临界值为-5mm。根据该值，将患者分为两组：短组（距环状软骨的距离≥-5mm）和长组（距环状软骨的距离<-5mm）。除体重指数外，两组的临床病理因素无显著差异。在单因素分析中，短组的3年总生存率显著较低（45.4%对79.6%；P=0.009）。在多因素分析中，短组是一个独立的预后危险因素（风险比=2.65；P=0.039）。这可能是由于颈段食管周围的淋巴引流所致。
