甲硝唑常规治疗难治性滴虫性阴道炎的管理
Managing trichomonal vaginitis refractory to conventional treatment with metronidazole.
作者信息
Ahmed-Jushuf I H, Murray A E, McKeown J
机构信息
Department of Genitourinary Medicine, Royal Hospital, Liverpool.
出版信息
Genitourin Med. 1988 Feb;64(1):25-9. doi: 10.1136/sti.64.1.25.
Abstract
Three patients with vulvovaginitis caused by Trichomonas vaginalis, which was refractory to conventional treatment with metronidazole are described. The T vaginalis strain isolated from one patient was resistant to metronidazole (minimum inhibitory concentration (MIC) more than 100 mg/l) under aerobic conditions, although under anaerobic conditions it was as susceptible as a normal reference strain. The effect of the concomitant use of other medication and the influence of other vaginal pathogens on the efficacy of metronidazole are highlighted.
摘要
本文描述了3例滴虫性阴道炎患者，这些患者对甲硝唑的常规治疗无效。从1例患者分离出的阴道毛滴虫菌株在有氧条件下对甲硝唑耐药（最低抑菌浓度（MIC）超过100mg/l），而在厌氧条件下其敏感性与正常参考菌株相同。文中强调了同时使用其他药物的影响以及其他阴道病原体对甲硝唑疗效的影响。
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