Department of Neurology & Algology, Gazi University Hospital, Ankara, Turkey.
Headache. 2020 Sep;60(8):1788-1792. doi: 10.1111/head.13940. Epub 2020 Aug 17.
Headache was reported in up to one-third of the hospitalized patients; yet, the clinical characteristics of headache associated with coronavirus disease 2019 (COVID-19) have not been defined. This observational case study included patients who were consulted to headache unit due to headache and had COVID-19 illness. Headache features in 13 PCR-confirmed COVID-19 patients with mild symptoms were reported. Headache was the isolated symptom of the COVID-19 in 3 patients and emerged as an early symptom during the disease course in all patients. Patients specified severe, rapid onset, unrelenting headache with migraine-like features, as well as unusual sensory symptoms such as anosmia, and gastrointestinal symptoms such as diarrhea and loss of appetite and weight. Headache lasted up to 3 days in 70% of the patients and resolved in all patients within 2 weeks. Despite the fact that most of the patients were female and headache characteristics were suggestive of migraine, majority of patients were not suffering from primary headaches. It was concluded that headache could be an isolated symptom of COVID-19, which might possibly be ignored in asymptomatic patients. Headaches associated with COVID-19 included features resembling migraine and/or atypical symptoms including anosmia and diarrhea.
多达三分之一的住院患者会出现头痛；然而，与 2019 年冠状病毒病（COVID-19）相关的头痛的临床特征尚未确定。这项观察性病例研究纳入了因头痛而到头痛科就诊且患有 COVID-19 的患者。报告了 13 名经 PCR 确诊的 COVID-19 轻症患者的头痛特征。3 名患者的 COVID-19 仅表现为头痛，所有患者的头痛均为疾病早期出现的症状。患者具体描述为严重、快速发作、持续不断的头痛，具有偏头痛样特征，以及不常见的感觉症状，如嗅觉丧失，以及胃肠道症状，如腹泻、食欲不振和体重减轻。70%的患者头痛持续长达 3 天，所有患者均在 2 周内缓解。尽管大多数患者为女性，且头痛特征提示偏头痛，但大多数患者并非原发性头痛。研究得出结论，头痛可能是 COVID-19 的孤立症状，在无症状患者中可能会被忽视。COVID-19 相关头痛包括类似于偏头痛的特征和/或不典型症状，包括嗅觉丧失和腹泻。
