文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain.

作者信息

Fodoulian Leon, Tuberosa Joël, Rossier Daniel, Boillat Madlaina, Kan Chenda, Pauli Véronique, Egervari Kristof, Lobrinus Johannes A, Landis Basile N, Carleton Alan, Rodriguez Ivan

机构信息

Department of Genetics and Evolution, Faculty of Sciences, University of Geneva, quai Ernest-Ansermet 30, 1211 Geneva, Switzerland.

Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland.

出版信息

iScience. 2020 Dec 18;23(12):101839. doi: 10.1016/j.isci.2020.101839. Epub 2020 Nov 25.

DOI:10.1016/j.isci.2020.101839
PMID:33251489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7685946/
Abstract

Reports indicate an association between COVID-19 and anosmia, as well as the presence of SARS-CoV-2 virions in the olfactory bulb. To test whether the olfactory neuroepithelium may represent a target of the virus, we generated RNA-seq libraries from human olfactory neuroepithelia, in which we found substantial expression of the genes coding for the virus receptor angiotensin-converting enzyme-2 (ACE2) and for the virus internalization enhancer TMPRSS2. We analyzed a human olfactory single-cell RNA-seq dataset and determined that sustentacular cells, which maintain the integrity of olfactory sensory neurons, express and . ACE2 protein was highly expressed in a subset of sustentacular cells in human and mouse olfactory tissues. Finally, we found transcripts in specific brain cell types, both in mice and humans. Sustentacular cells thus represent a potential entry door for SARS-CoV-2 in a neuronal sensory system that is in direct connection with the brain.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/8cd5bbf9d246/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/e69a79532136/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/cf824bb1c592/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/e0f9a137ed56/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/ccca2c6338aa/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/311bd0718f53/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/8cd5bbf9d246/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/e69a79532136/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/cf824bb1c592/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/e0f9a137ed56/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/ccca2c6338aa/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/311bd0718f53/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99c6/7721638/8cd5bbf9d246/gr5.jpg

相似文献

[1]
SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain.

iScience. 2020-12-18

[2]
Evidence of SARS-CoV2 Entry Protein ACE2 in the Human Nose and Olfactory Bulb.

Cells Tissues Organs. 2020

[3]
Supporting Cells of the Human Olfactory Epithelium Co-Express the Lipid Scramblase TMEM16F and ACE2 and May Cause Smell Loss by SARS-CoV-2 Spike-Induced Syncytia.

Cell Physiol Biochem. 2022-6-7

[4]
Knockout of angiotensin converting enzyme-2 receptor leads to morphological aberrations in rodent olfactory centers and dysfunctions associated with sense of smell.

Front Neurosci. 2023-6-19

[5]
The Cellular basis of loss of smell in 2019-nCoV-infected individuals.

Brief Bioinform. 2021-3-22

[6]
Pathophysiological relationship between COVID-19 and olfactory dysfunction: A systematic review.

Braz J Otorhinolaryngol. 2022

[7]
Infectivity of Human Olfactory Neurons to SARS-CoV-2: A Link to Anosmia.

Oman Med J. 2021-9-30

[8]
Co-expression of the SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in human ovaries: Identification of cell types and trends with age.

Genomics. 2021-11

[9]
Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin.

mSphere. 2021-4-14

[10]
Negative correlation between ACE2 gene expression levels and loss of taste in a cohort of COVID-19 hospitalized patients: New clues to long-term cognitive disorders.

Front Cell Infect Microbiol. 2022

引用本文的文献

[1]
Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection.

NPJ Parkinsons Dis. 2025-4-23

[2]
Expression of SARS-CoV-2 entry receptor ACE2 in human brain and its association with Alzheimer's disease and COVID-19.

Mol Psychiatry. 2025-4-6

[3]
Single-cell transcriptomics reveals a compartmentalized antiviral interferon response in the nasal epithelium of mice.

J Virol. 2025-3-18

[4]
Cells that survive acute SARS-CoV-2 infection contribute to inflammation and lung regeneration in mice.

mBio. 2025-3-12

[5]
Development of an rpS6-Based Ex Vivo Assay for the Analysis of Neuronal Activity in Mouse and Human Olfactory Systems.

Int J Mol Sci. 2024-12-7

[6]
SARS-CoV-2 Infection and Alpha-Synucleinopathies: Potential Links and Underlying Mechanisms.

Int J Mol Sci. 2024-11-10

[7]
Neuroimmune interactions in the olfactory epithelium: maintaining a sensory organ at an immune barrier interface.

Trends Immunol. 2024-12

[8]
Elimination of olfactory sensory neurons by zinc sulfate inoculation prevents SARS-CoV-2 infection of the brain in K18-hACE2 transgenic mice.

Sci Rep. 2024-11-13

[9]
Polyunsaturated Fatty Acids as Potential Treatments for COVID-19-Induced Anosmia.

Biomedicines. 2024-9-12

[10]
The Interplay between Airway Cilia and Coronavirus Infection, Implications for Prevention and Control of Airway Viral Infections.

Cells. 2024-8-14

本文引用的文献

[1]
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells.

Signal Transduct Target Ther. 2020-12-4

[2]
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.

Sci Adv. 2020-7-24

[3]
COVID-19 and the Chemical Senses: Supporting Players Take Center Stage.

Neuron. 2020-7-1

[4]
The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings.

Brain. 2020-10-1

[5]
Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters.

Brain Behav Immun. 2020-7-3

[6]
Real-time tracking of self-reported symptoms to predict potential COVID-19.

Nat Med. 2020-5-11

[7]
Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age.

ACS Chem Neurosci. 2020-5-19

[8]
Cell entry mechanisms of SARS-CoV-2.

Proc Natl Acad Sci U S A. 2020-5-6

[9]
Olfactory and Gustatory Dysfunction in Coronavirus Disease 2019 (COVID-19).

Clin Infect Dis. 2020-11-19

[10]
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.

Nat Med. 2020-5

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索