Hattori N, Kato Y, Murakami Y, Hashida S, Ishikawa E, Mohri Z, Imura H
Department of Medicine, Kyoto University Faculty of Medicine, Japan.
J Clin Endocrinol Metab. 1988 Apr;66(4):727-32. doi: 10.1210/jcem-66-4-727.
An ultrasensitive enzyme immunoassay was used to measure urinary GH levels in patients with renal insufficiency and normal subjects. Urinary GH excretion varied widely, but was significantly higher (P less than 0.01) in patients with renal insufficiency (median, 339; range, 2-17,000 ng/day) than in normal subjects (5.4; 1.2-15 ng/day). Urinary GH excretion correlated positively with urinary beta 2-microglobulin excretion (r = 0.79; P less than 0.001) and negatively with creatinine clearance (r = -0.83; P less than 0.001). Gel chromatography of urine from patients with renal insufficiency revealed a major peak of urinary GH corresponding to a mol wt of 22K, that of pituitary GH. These findings suggest that the kidneys play an important role in the catabolism of GH and that urinary GH may reflect, at least in part, renal function as well as hypothalamo-pituitary function.
采用超敏酶免疫分析法测定肾功能不全患者和正常受试者的尿生长激素（GH）水平。尿GH排泄量差异很大，但肾功能不全患者（中位数为339；范围为2 - 17,000 ng/天）的尿GH排泄量显著高于正常受试者（5.4；1.2 - 15 ng/天）（P < 0.01）。尿GH排泄与尿β2-微球蛋白排泄呈正相关（r = 0.79；P < 0.001），与肌酐清除率呈负相关（r = -0.83；P < 0.001）。对肾功能不全患者的尿液进行凝胶色谱分析，发现尿GH的一个主要峰对应于分子量为22K的垂体GH。这些发现表明，肾脏在GH的分解代谢中起重要作用，尿GH可能至少部分反映肾功能以及下丘脑 - 垂体功能。
