Yang Liren, Shang Li, Wang Shanshan, Yang Wenfang, Huang Liyan, Qi Cuifang, Gurcan Anil, Yang Zixuan, Chung Mei Chun
Department of Obstetrics and Gynecology, Maternal & Child Health Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.
School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, P.R. China.
PLoS One. 2020 Aug 13;15(8):e0236708. doi: 10.1371/journal.pone.0236708. eCollection 2020.
Polycyclic aromatic hydrocarbons (PAHs) are a kind of endocrine disruptors, which can enter human body by the inhalation of PAH-containing matter and the ingestion of PAH-containing foodstuffs. Studies showed that PAHs can cross the placental barrier and might cause adverse effects on the fetus.
This meta-analysis aimed to estimate the associations between prenatal exposure to PAHs and birth weight.
Articles published in English until May 8, 2020 and reported the effects of prenatal exposure to PAHs on birth weight were searched in multiple electronic databases including PubMed, the Web of Science, EMBASE and the Cochrane Library. The included studies were divided into three groups in accordance with the measurement of PAHs exposure. Then coefficient was extracted, conversed and synthesized by random-effects meta-analysis. And risk of bias was assessed for each study.
A total of 3488 citations were searched and only 11 studies were included finally after double assessment. We found that there were no association between PAH-DNA adducts in cord blood (low/high) (OR: 1.0, 95%CI: 0.97, 1.03), 1-hydroxy pyrene (1-HP) concentration in maternal urine (OR: 1.0, 95%CI: 0.97, 1.03) and prenatal maternal airborne PAHs exposure (OR: 0.97, 95%CI: 0.93, 1.01) and birth weight. However, we observed ethnicity may change the effects of PAHs exposure on birth weight.
There is no significant relationship between prenatal exposure to PAHs and birth weight in our meta-analysis. Further studies are still needed for determining the effects of prenatal PAHs exposure on birth weight.
多环芳烃（PAHs）是一类内分泌干扰物，可通过吸入含PAH的物质以及摄入含PAH的食物进入人体。研究表明，PAHs可穿过胎盘屏障并可能对胎儿产生不良影响。
本荟萃分析旨在评估产前暴露于PAHs与出生体重之间的关联。
在包括PubMed、科学网、EMBASE和Cochrane图书馆在内的多个电子数据库中检索截至2020年5月8日发表的英文文章，这些文章报道了产前暴露于PAHs对出生体重的影响。根据PAHs暴露的测量方法，将纳入的研究分为三组。然后通过随机效应荟萃分析提取、转换并合成系数。并对每项研究进行偏倚风险评估。
共检索到3488条引文，经过双重评估后最终仅纳入11项研究。我们发现，脐血中PAH-DNA加合物（低/高）（OR：1.0，95%CI：0.97，1.03）、母体尿液中1-羟基芘（1-HP）浓度（OR：1.0，95%CI：0.97，1.03）以及产前母体空气中PAHs暴露（OR：0.97，95%CI：0.93，1.01）与出生体重之间无关联。然而，我们观察到种族可能会改变PAHs暴露对出生体重的影响。
在我们的荟萃分析中，产前暴露于PAHs与出生体重之间无显著关系。仍需要进一步研究以确定产前PAHs暴露对出生体重的影响。
