NIHR ARC South West Peninsula, University of Exeter, Exeter, Devon, United Kingdom.
Wessex Kidney Centre, Portsmouth Hospitals University NHS Trust, Portsmouth, Hants, United Kingdom.
PLoS One. 2020 Aug 13;15(8):e0237628. doi: 10.1371/journal.pone.0237628. eCollection 2020.
This study presents two simulation modelling tools to support the organisation of networks of dialysis services during the COVID-19 pandemic. These tools were developed to support renal services in the South of England (the Wessex region caring for 650 dialysis patients), but are applicable elsewhere. A discrete-event simulation was used to model a worst case spread of COVID-19, to stress-test plans for dialysis provision throughout the COVID-19 outbreak. We investigated the ability of the system to manage the mix of COVID-19 positive and negative patients, the likely effects on patients, outpatient workloads across all units, and inpatient workload at the centralised COVID-positive inpatient unit. A second Monte-Carlo vehicle routing model estimated the feasibility of patient transport plans. If current outpatient capacity is maintained there is sufficient capacity in the South of England to keep COVID-19 negative/recovered and positive patients in separate sessions, but rapid reallocation of patients may be needed. Outpatient COVID-19 cases will spillover to a secondary site while other sites will experience a reduction in workload. The primary site chosen to manage infected patients will experience a significant increase in outpatients and inpatients. At the peak of infection, it is predicted there will be up to 140 COVID-19 positive patients with 40 to 90 of these as inpatients, likely breaching current inpatient capacity. Patient transport services will also come under considerable pressure. If patient transport operates on a policy of one positive patient at a time, and two-way transport is needed, a likely scenario estimates 80 ambulance drive time hours per day (not including fixed drop-off and ambulance cleaning times). Relaxing policies on individual patient transport to 2-4 patients per trip can save 40-60% of drive time. In mixed urban/rural geographies steps may need to be taken to temporarily accommodate renal COVID-19 positive patients closer to treatment facilities.
本研究提出了两种仿真建模工具,以支持在 COVID-19 大流行期间组织透析服务网络。这些工具是为支持英格兰南部(为 650 名透析患者提供服务的 Wessex 地区)的肾脏服务而开发的,但也可在其他地方应用。使用离散事件仿真来模拟 COVID-19 的最坏传播情况,以对整个 COVID-19 爆发期间的透析服务提供计划进行压力测试。我们研究了系统管理 COVID-19 阳性和阴性患者混合的能力、对所有单位的门诊工作量以及集中 COVID-19 阳性住院患者单位的住院工作量的可能影响。第二个蒙特卡罗车辆路径模型估计了患者运输计划的可行性。如果维持当前的门诊能力,那么英格兰南部有足够的能力将 COVID-19 阴性/康复患者和阳性患者分开进行治疗,但可能需要快速重新分配患者。门诊 COVID-19 病例将溢出到备用站点,而其他站点的工作量将减少。选择管理感染患者的主要站点将经历门诊和住院患者人数的显著增加。在感染高峰期,预计将有多达 140 名 COVID-19 阳性患者,其中 40 至 90 名患者为住院患者,可能会突破当前的住院能力。患者运输服务也将面临巨大压力。如果患者运输按照每次一名阳性患者的政策运行,并且需要双向运输,则一个可能的方案估计每天需要 80 次救护车行驶时间(不包括固定的下车和救护车清洁时间)。如果将个别患者的运输政策放宽至每次 2-4 名患者,则可以节省 40-60%的行驶时间。在混合城市/农村的地理环境中,可能需要采取措施暂时将肾脏 COVID-19 阳性患者安置在更接近治疗设施的地方。