Mietto Cristina, Salice Valentina, Ferraris Matteo, Zuccon Gianmarco, Valdambrini Federico, Piazzalunga Giorgio, Socrate Anna Maria, Radrizzani Danilo
Department of Anesthesia and Critical Care, ASST Ovest Milanese - Ospedale di Legnano, Legnano, Italy.
Department of Anesthesia and Critical Care, ASST Ovest Milanese - Ospedale di Legnano, Legnano, Italy.
Ann Vasc Surg. 2020 Nov;69:80-84. doi: 10.1016/j.avsg.2020.08.004. Epub 2020 Aug 11.
Novel 2019 coronavirus (COVID-19) infection usually causes a respiratory disease that may vary in severity from mild symptoms to severe pneumonia with multiple organ failure. Coagulation abnormalities are frequent, and reports suggest that COVID-19 may predispose to venous and arterial thrombotic complications. We report a case of acute lower limb ischemia and resistance to heparin as the onset of COVID-19 disease, preceding the development of respiratory failure. This case highlights that the shift of coagulation profile toward hypercoagulability was associated with the acute ischemic event and influenced the therapy.
新型2019冠状病毒（COVID-19）感染通常会引发一种呼吸系统疾病，其严重程度可能从轻微症状到伴有多器官衰竭的严重肺炎不等。凝血异常很常见，报告表明COVID-19可能易引发静脉和动脉血栓并发症。我们报告一例急性下肢缺血且对肝素耐药的病例，该病例为COVID-19疾病发作，先于呼吸衰竭出现。该病例突出表明，凝血状态向高凝性的转变与急性缺血事件相关，并影响了治疗。
