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Parasite polymorphism present within minimal T cell epitopes of Plasmodium falciparum circumsporozoite protein.

作者信息

Good M F, Pombo D, Maloy W L, de la Cruz V F, Miller L H, Berzofsky J A

机构信息

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.

出版信息

J Immunol. 1988 Mar 1;140(5):1645-50.

PMID:3279121
Abstract

Identification of T cell antigenic sites is critical for antisporozoite malarial vaccine design. Here, we present data that define two minimal functional T cell sites present in an immunogenic domain of the circumsporozoite protein of Plasmodium falciparum. These two sites overlap one another and correlate with polymorphic regions of the molecule. This suggests that these polymorphisms may be a result of pressure from immune T cells.

摘要

相似文献

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Parasite polymorphism present within minimal T cell epitopes of Plasmodium falciparum circumsporozoite protein.
J Immunol. 1988 Mar 1;140(5):1645-50.
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Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule.人类对恶性疟原虫环子孢子蛋白的T细胞识别:免疫显性T细胞结构域定位于该分子的多态性区域。
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