Department of Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital, Baylor College of Medicine, 6621 Fannin Street, A330, Houston, TX 77030, USA.
Department of Anesthesiology, Perioperative and Pain Medicine, Texas Children's Hospital, Baylor College of Medicine, 6621 Fannin Street, A330, Houston, TX 77030, USA.
Anesthesiol Clin. 2020 Sep;38(3):693-707. doi: 10.1016/j.anclin.2020.05.004. Epub 2020 Jul 16.
Pediatric obstructive sleep apnea affects a large number of children and has multiple end-organ sequelae. Although many of these have been demonstrated to be reversible, the effects on some of the organ systems, including the brain, have not shown easy reversibility. Progress in this area has been hampered by lack of a preclinical model to study the disease. Therefore, perioperative and sleep physicians are tasked with making a number of difficult decisions, including optimal surgical timing to prevent disease evolution, but also to keep the perioperative morbidity in a safe range for these patients.
小儿阻塞性睡眠呼吸暂停影响大量儿童，并导致多种终末器官后遗症。虽然已经证实其中许多后遗症是可逆的，但对包括大脑在内的一些器官系统的影响尚未显示出易于逆转的迹象。该领域的进展受到缺乏临床前模型来研究该疾病的阻碍。因此，围手术期和睡眠医师面临着许多困难的决策，包括最佳手术时机以防止疾病进展，但也要将围手术期发病率控制在这些患者的安全范围内。
