Nakahara H, Ishikawa T, Sarai Y, Kondo I, Kozukue H
Antimicrob Agents Chemother. 1977 Jun;11(6):999-1003. doi: 10.1128/AAC.11.6.999.
The mercury and antibiotic resistance of 338 strains of Escherichia coli isolated from hospital patients was determined. Resistance to mercury was found in 58.6% of the isolates. The frequencies of resistance to streptomycin (Sm), tetracycline (Tc), chloramphenicol (Cm), kanamycin (Kan), cephaloridine (Cer), and gentamicin (Gm) were 66.3, 60.3, 56.5, 42.9, 32.1, and 1.5%, respectively. Among the above, 198 mercury- and antibiotic-resistant isolates were selected and tested for their ability to transfer the resistance to susceptible strains of E. coli K-12 and Klebsiella pneumoniae JK5. R plasmids carrying mercury resistance were demonstrated in 89.9% of the mercury-resistant strains of E. coli. Furthermore, R(Hg,Sm,Tc,Cm) plasmids were demonstrated most frequently, followed by R(Hg,Sm,Tc,Cm,Kan), R(Hg,Cm,Kan), and R(Hg,Sm,Tc,Cm,Kan,Cer) plasmids.
对从医院患者中分离出的338株大肠杆菌的汞和抗生素抗性进行了测定。在58.6%的分离株中发现了对汞的抗性。对链霉素（Sm）、四环素（Tc）、氯霉素（Cm）、卡那霉素（Kan）、头孢菌素（Cer）和庆大霉素（Gm）的抗性频率分别为66.3%、60.3%、56.5%、42.9%、32.1%和1.5%。其中，选择了198株耐汞和抗生素的分离株，测试它们将抗性转移至大肠杆菌K-12和肺炎克雷伯菌JK5敏感菌株的能力。在89.9%的耐汞大肠杆菌菌株中证实了携带汞抗性的R质粒。此外，R（Hg，Sm，Tc，Cm）质粒最为常见，其次是R（Hg，Sm，Tc，Cm，Kan）、R（Hg，Cm，Kan）和R（Hg，Sm，Tc，Cm，Kan，Cer）质粒。
