Kanai H, Hashimoto H, Mitsuhashi S
Microbiol Immunol. 1983;27(6):471-8. doi: 10.1111/j.1348-0421.1983.tb00606.x.
In 1978, 1,021 Escherichia coli strains were isolated from 105 field broilers (F) and 1,058 strains from 106 broilers in a zootechnical experiment station (Z), and their drug-resistance patterns and the presence of conjugative R plasmids were compared. The resistance markers examined were tetracycline (TC), chloramphenicol (CM), streptomycin (SM), sulfonamides (SA), kanamycin (KM), and ampicillin (APC). The populations of individuals that excreted resistant strains were 100% in F and 58% in Z. Frequencies of isolation of drug-resistant strains among the total isolates were 93% in F and 36% in Z, indicating that the resistant strains are a rather high proportion of the intestinal flora in F but are slightly less prevalent in Z. The resistance pattern to (TC.SM.SA.KM) was seen at the highest frequency in both groups. Conjugative R plasmids were demonstrated more frequently in field broilers (F). The results reflect the wide use of antibiotics in the livestock industry, resulting in the appearance of drug-resistant strains mostly due to the presence of R plasmids.
1978年，从105只商品肉鸡（F）中分离出1021株大肠杆菌，从一个畜牧试验站（Z）的106只肉鸡中分离出1058株大肠杆菌，并比较了它们的耐药模式以及接合性R质粒的存在情况。检测的耐药标记物有四环素（TC）、氯霉素（CM）、链霉素（SM）、磺胺类药物（SA）、卡那霉素（KM）和氨苄青霉素（APC）。排泄耐药菌株的个体群体在F组中为100%，在Z组中为58%。在所有分离菌株中，耐药菌株的分离频率在F组中为93%，在Z组中为36%，这表明耐药菌株在F组肠道菌群中占相当高的比例，但在Z组中略少。对（TC.SM.SA.KM）的耐药模式在两组中出现频率最高。接合性R质粒在商品肉鸡（F）中更频繁地被检测到。结果反映出抗生素在畜牧业中的广泛使用，这主要由于R质粒的存在导致了耐药菌株的出现。
