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哮喘气道重塑中的上皮-间充质转化受 IL-33/CD146 轴调节。

Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis.

机构信息

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.

出版信息

Front Immunol. 2020 Jul 22;11:1598. doi: 10.3389/fimmu.2020.01598. eCollection 2020.

DOI:10.3389/fimmu.2020.01598
PMID:32793232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7387705/
Abstract

Epithelial-mesenchymal transition (EMT) is essential in asthma airway remodeling. IL-33 from epithelial cells is involved in pulmonary fibrosis. CD146 has been extensively explored in cancer-associated EMT. Whether IL-33 regulates CD146 in the EMT process associated with asthma airway remodeling is still largely unknown. We hypothesized that EMT in airway remodeling was regulated by the IL-33/CD146 axis. House dust mite (HDM) extract increased the expression of IL-33 and CD146 in epithelial cells. Increased expression of CD146 in HDM-treated epithelial cells could be blocked with an ST2-neutralizing antibody. Moreover, HDM-induced EMT was dependent on the CD146 and TGF-β/SMAD-3 signaling pathways. IL-33 deficiency decreased CD146 expression and alleviated asthma severity. Similarly, CD146 deficiency mitigated EMT and airway remodeling in a murine model of chronic allergic airway inflammation. Furthermore, CD146 expression was significantly elevated in asthma patients. We concluded that IL-33 from HDM extract-treated alveolar epithelial cells stimulated CD146 expression, promoting EMT in airway remodeling in chronic allergic inflammation.

摘要

上皮-间充质转化 (EMT) 在哮喘气道重塑中至关重要。上皮细胞中的白细胞介素 33 (IL-33) 参与肺纤维化。CD146 在癌症相关 EMT 中已被广泛研究。IL-33 是否调节哮喘气道重塑相关 EMT 过程中的 CD146 仍知之甚少。我们假设 EMT 在气道重塑中受到 IL-33/CD146 轴的调节。屋尘螨 (HDM) 提取物增加了上皮细胞中 IL-33 和 CD146 的表达。用 ST2 中和抗体可以阻断 HDM 处理的上皮细胞中 CD146 的高表达。此外，HDM 诱导的 EMT 依赖于 CD146 和 TGF-β/SMAD-3 信号通路。IL-33 缺乏会降低 CD146 的表达并减轻哮喘严重程度。同样，CD146 缺乏减轻了慢性变应性气道炎症小鼠模型中的 EMT 和气道重塑。此外，哮喘患者的 CD146 表达显著升高。我们得出结论，HDM 提取物处理的肺泡上皮细胞中的白细胞介素 33 刺激 CD146 的表达，促进慢性变应性炎症中气道重塑的 EMT。

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