Marzban Saba, Arbee Mohamed, Vorajee Naseema, Richards Guy A
Clinical Pharmacy, Netcare Christiaan Barnard Memorial Hospital, Cape Town, South Africa.
Clinical Haematology, Netcare Garden City Hospital, Johannesburg, Gauteng, South Africa.
Oxf Med Case Reports. 2020 Aug 10;2020(8):omz026. doi: 10.1093/omcr/omz026. eCollection 2020 Aug.
A 31-year old non-diabetic woman presented to our hospital with symptoms of dehydration, drowsiness, fatigue, shortness of breath and vomiting present for two consecutive days prior to admission. She had started a low carbohydrate, high fat (LCHF) diet to induce weight loss while breastfeeding her 4-month-old child 2 weeks prior to admission. The patient was found to have a severely high anion gap metabolic acidosis. It was determined to be due to ketoacidosis, which was as a result of carbohydrate restriction in the presence of increased metabolic demands related with the synthesis and secretion of milk. She denied alcohol use or ingestion of any drugs prior to admission. The patient underwent dialysis and received insulin, 5% dextrose water alongside a well-balanced diet with adequate calories. All abnormal laboratory results normalized and follow-up visits were done. Lactating women are at risk of developing ketoacidosis due to high metabolic demands of the body to produce milk. LCHF diets may exacerbate the body's demand to meet its milk production requirement and result in ketoacidosis. Health professionals need to be aware of the complications of LCHF diet in this population to prevent mortality associated with this condition.
一名31岁的非糖尿病女性因脱水、嗜睡、疲劳、呼吸急促和呕吐症状入院,这些症状在入院前已持续两天。入院前两周,她在母乳喂养4个月大的孩子时开始采用低碳水化合物、高脂肪(LCHF)饮食以减重。患者被发现患有严重的高阴离子间隙代谢性酸中毒。经确定这是由酮症酸中毒引起的,酮症酸中毒是在与乳汁合成和分泌相关的代谢需求增加的情况下,因碳水化合物摄入受限所致。她否认入院前饮酒或服用任何药物。患者接受了透析,并接受了胰岛素治疗,同时输注5%葡萄糖水,并搭配热量充足、营养均衡的饮食。所有异常的实验室检查结果均恢复正常,并进行了随访。由于身体产奶的高代谢需求,哺乳期女性有发生酮症酸中毒的风险。LCHF饮食可能会加剧身体满足产奶需求的负担,从而导致酮症酸中毒。医疗专业人员需要了解该人群中LCHF饮食的并发症,以预防与此病症相关的死亡。