Department of Medicine and Science of Aging, University Centre of Sports Medicine, University "G. d'Annunzio", Chieti, Italy.
Geriatric Unit, Azienda Toscana Centro, Florence, Italy.
Osteoporos Int. 2021 Feb;32(2):353-362. doi: 10.1007/s00198-020-05585-9. Epub 2020 Aug 13.
The aim of this study was to evaluate the association of levels of urinary total polyphenols considered as a proxy measure of polyphenol intake, with longitudinal changes of bone properties, in the InCHIANTI study. Dietary intake of polyphenols appears to be associated with future accelerated deterioration of bone health.
Polyphenols, micronutrients ingested through plant-based foods, have antioxidant and anti-inflammatory properties and may contribute to osteoporosis prevention. We evaluated associations of high levels of urinary total polyphenols (UTP), a proxy measure of polyphenol intake, with longitudinal changes of bone properties in a representative cohort of free-living participants of the InCHIANTI study.
The InCHIANTI study enrolled representative samples from the registry list of two towns in Tuscany, Italy. Baseline data were collected in 1998 and follow-up visits in 2001 and 2004. Of the 1453 participants enrolled, 956 consented to donate a 24-h urine sample used to assess UTP, had dietary assessment, a physical examination, and underwent a quantitative computerized tomography (pQCT) of the tibia. From pQCT images, we estimated markers of bone mass (BM), diaphyseal design (DD), and material quality (MQ). Mixed models were used to study the relationship between baseline tertiles of UTP with changes of the bone characteristics over the follow-up.
At baseline, higher levels of UTP were positively correlated with markers of BM, DD, and MQ. Compared with lower tertile of UTP, participants in the intermediate and highest tertiles had higher cortical bone area, cortical mineral content, and cortical thickness. However, participants in the intermediate and highest UTP tertiles experienced accelerated deterioration of these same parameters over the follow-up compared with those in the lowest UTP tertile.
Dietary intake of polyphenols estimated by UTP and dietary questionnaire was associated with long-term accelerated deterioration of bone health. Our study does not support the recommendation of increasing polyphenol intake for osteoporosis prevention.
本研究旨在评估尿总多酚水平（作为多酚摄入量的替代指标）与 INCHIANTI 研究中骨骼特性的纵向变化之间的关联。多酚的饮食摄入似乎与未来骨骼健康恶化加速有关。
多酚是从植物性食物中摄取的微量营养素，具有抗氧化和抗炎特性，可能有助于预防骨质疏松症。我们评估了尿总多酚（UTP）水平较高（作为多酚摄入量的替代指标）与 INCHIANTI 研究中自由生活参与者代表性队列的骨骼特性纵向变化之间的关联。
INCHIANTI 研究从意大利托斯卡纳两个城镇的登记册名单中招募了具有代表性的样本。基线数据于 1998 年收集，随访于 2001 年和 2004 年进行。在 1453 名入组的参与者中，有 956 名同意捐赠 24 小时尿液样本用于评估 UTP，进行饮食评估、体检，并接受胫骨定量计算机断层扫描（pQCT）。从 pQCT 图像中，我们估计了骨量（BM）、骨干设计（DD）和材料质量（MQ）的标志物。混合模型用于研究基线 UTP 三分位数与随访期间骨骼特征变化之间的关系。
在基线时，较高的 UTP 水平与 BM、DD 和 MQ 的标志物呈正相关。与 UTP 较低三分位组相比，中三分位和最高三分位组的皮质骨面积、皮质骨矿物质含量和皮质厚度更高。然而，与 UTP 最低三分位组相比，中三分位和最高 UTP 三分位组在随访期间这些参数的恶化速度更快。
通过 UTP 和饮食问卷估计的多酚饮食摄入与骨骼健康长期加速恶化有关。我们的研究不支持增加多酚摄入以预防骨质疏松症的建议。
