Urpi-Sarda Mireia, Andres-Lacueva Cristina, Rabassa Montserrat, Ruggiero Carmelinda, Zamora-Ros Raul, Bandinelli Stefania, Ferrucci Luigi, Cherubini Antonio
Biomarkers and Nutrimetabolomic Lab., Nutrition and Food Science Department, XaRTA, INSA, Pharmacy School, University of Barcelona, Spain. Ingenio-CONSOLIDER Program, FUN-C-FOOD, Barcelona, Spain.
Department of Medicine, Institute of Gerontology and Geriatrics, Perugia University, Italy.
J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1141-7. doi: 10.1093/gerona/glv026. Epub 2015 Apr 2.
Frailty, an age-related state of increased vulnerability, is associated with a higher risk of multiple adverse events. Studies have suggested that the quality of dietary intake may affect the development of frailty. We hypothesized that frailty in older subjects would be associated with dietary total polyphenols (DTP) intake and its biomarker, urinary total polyphenols (UTP).
The Invecchiare in Chianti (InCHIANTI) Study is a prospective cohort study set in the Chianti area (Italy). We used data at baseline from 811 participants aged 65 years and older. UTP was determined using the Folin-Ciocalteu assay after solid-phase extraction. DTP was estimated using a validated Food Frequency Questionnaire and our own polyphenol database. The frailty, prefrailty, and nonfrailty states were defined according to the Fried and colleagues' criteria. Multinomial logistic regressions adjusted for potential confounders were used to assess the relationship between polyphenols and frailty.
Both DTP and UTP concentrations progressively decrease from nonfrail to frail participants. Participants in the highest UTP tertile compared to those in the lowest tertile were significantly less likely to be both frail (odds ratio [OR] = 0.36 [0.14-0.88], p = .025) and prefrail (OR = 0.64 [0.42-0.98], p = .038). Exhaustion and slowness were the only individual frailty criteria significantly associated with UTP tertiles. No significant association was observed between frailty and DTP, after adjustment for covariates.
High concentrations of UTP were associated with lower prevalence of frailty and prefrailty in an older community-dwelling population. A polyphenol-rich diet may protect against frailty in older persons. Our findings should be confirmed in longitudinal studies.
衰弱是一种与年龄相关的脆弱性增加状态，与多种不良事件的较高风险相关。研究表明，饮食摄入质量可能影响衰弱的发展。我们假设老年受试者的衰弱与膳食总多酚（DTP）摄入量及其生物标志物尿总多酚（UTP）有关。
基安蒂地区衰老研究（InCHIANTI）是一项在意大利基安蒂地区开展的前瞻性队列研究。我们使用了811名65岁及以上参与者的基线数据。UTP在固相萃取后采用福林-酚试剂法测定。DTP使用经过验证的食物频率问卷和我们自己的多酚数据库进行估算。根据弗里德及其同事的标准定义衰弱、前期衰弱和非衰弱状态。采用经潜在混杂因素调整的多项逻辑回归来评估多酚与衰弱之间的关系。
从非衰弱参与者到衰弱参与者，DTP和UTP浓度均逐渐降低。与最低三分位数组的参与者相比，最高UTP三分位数组的参与者同时出现衰弱（比值比[OR]=0.36[0.14 - 0.88]，p = 0.025）和前期衰弱（OR = 0.64[0.42 - 0.98]，p = 0.038）的可能性显著降低。疲惫和行动迟缓是与UTP三分位数显著相关的仅有的个体衰弱标准。在对协变量进行调整后，未观察到衰弱与DTP之间存在显著关联。
在老年社区居住人群中，高浓度的UTP与较低的衰弱和前期衰弱患病率相关。富含多酚的饮食可能预防老年人衰弱。我们的研究结果应在纵向研究中得到证实。
