Biochemistry Unit, Science Laboratory Technology Department, Federal Polytechnic Ede, Ede, Nigeria.
Biochemistry Department, Federal University of Technology, Akure, Nigeria.
J Food Biochem. 2021 Mar;45(3):e13435. doi: 10.1111/jfbc.13435. Epub 2020 Aug 14.
We investigated the effect of extracts from the leaf (ALE) and stem bark (ABE) of Almond tree on activities of some crucial enzymes [angiotensin-1 converting enzyme (ACE), arginase, acetylcholinesterase (AChE), phosphodiesterase-5 (PDE-5), adenosine deaminase (ADA), superoxide dismutase (SOD), catalase], and thiobarbituric acid reactive species (TBARS) associated with hypertension in normal adult male Wistar albino rats and Cyclosporine A (CsA)-stressed rats. The result revealed that CsA-stressed rats treated with captopril and extracts (ALE and ABE) had lowered ACE, arginase, AChE, PDE-5, ADA activities, and TBARS level, coupled with improved SOD and catalase activities compared with untreated CsA-stressed rats, which had reversed these biochemicals compared to normal rats. This suggests that the extracts could be explored to suppress hypertension and other cardiac injury known with CsA treatment; the potentials that could be linked with the constituent polyphenols. However, further studies including blood pressure should be determined to ascertain this claim. PRACTICAL APPLICATIONS: Drug-induced cardiotoxicity, hypertension, and organ damage are among the most common side effects of pharmaceutics. Therefore, it becomes imperative to find natural, effective, and alternative therapy with little or no side effect to combat drug toxicity. The use of Almond (leaf and stem bark) in folklore for the treatment/management of hypertension and other heart-related diseases without full scientific basis is on the increase. Hence, this study provides some biochemical evidences on the effect of Almond leaf and stem back extracts on crucial enzymes and oxidative stress markers involve in the incidence of hypertension in the course of Cyclosporine A administration. The findings of this study indicated that the studied plant materials could be promoted as nutraceutical agents to neutralize drug-induced cardiac injury and hypertension.
我们研究了杏仁树的叶（ALE）和茎皮（ABE）提取物对一些关键酶[血管紧张素转换酶（ACE）、精氨酸酶、乙酰胆碱酯酶（AChE）、磷酸二酯酶-5（PDE-5）、腺苷脱氨酶（ADA）、超氧化物歧化酶（SOD）、过氧化氢酶]和与高血压相关的丙二醛（TBARS）活性的影响，这些酶存在于正常成年雄性 Wistar 白化大鼠和环孢素 A（CsA）应激大鼠中。结果表明，与未用卡托普利和提取物（ALE 和 ABE）治疗的 CsA 应激大鼠相比，用卡托普利和提取物（ALE 和 ABE）治疗的 CsA 应激大鼠的 ACE、精氨酸酶、AChE、PDE-5、ADA 活性和 TBARS 水平降低，同时 SOD 和过氧化氢酶活性提高，与正常大鼠相比，这些生化指标得到了逆转。这表明，这些提取物可能被用来抑制高血压和其他已知与 CsA 治疗相关的心脏损伤；这些潜力可能与多酚类成分有关。然而，为了确定这一说法，还需要进行包括血压在内的进一步研究。
药物引起的心脏毒性、高血压和器官损伤是药剂学中最常见的副作用之一。因此，寻找天然、有效、副作用小或无的替代疗法来对抗药物毒性变得至关重要。杏仁（叶和茎皮）在民间用于治疗/管理高血压和其他与心脏相关疾病的用途越来越多，但缺乏充分的科学依据。因此，本研究提供了一些关于杏仁叶和茎皮提取物对环孢素 A 给药过程中涉及高血压发生的关键酶和氧化应激标志物的影响的生化证据。研究结果表明，研究的植物材料可作为营养保健品，以中和药物引起的心脏损伤和高血压。
