Functional Foods and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
Biochemistry Unit, Department of Chemical Sciences, Joseph Ayo Babalola University, Ikeji Arakeji, Nigeria.
Biomarkers. 2023 Dec;28(5):416-426. doi: 10.1080/1354750X.2023.2198680. Epub 2023 Apr 10.
The present study aimed at investigating the effect of fruits on blood pressure, NO/cGMP signalling pathway, angiotensin-1-converting enzyme and arginase activity, and oxidative stress biomarkers in L-NAME-induced hypertensive rats.
Forty-two Wistar rats were divided into seven groups. Hypertension was induced via oral administration of 40 mg/kg of L-NAME for 21 days. Thereafter, the hypertensive rats were treated with fruit-supplemented diet and sildenafil citrate for 21 days. The blood pressure was measured and cardiac homogenate was prepared for biochemical analyses.
The results showed that L-NAME caused a significant ( < 0.05) increase in systolic and diastolic blood pressure, and heart rate as well as ACE, arginase and PDE-5 activity, with a simultaneous decrease in NO and HS levels as well as increased oxidative stress biomarkers. However, treatment with fruits-supplemented diets and sildenafil citrate lowered blood pressure and modulated ACE, arginase, and PDE-5 activity, improved NO and HS levels, as well as antioxidant status.
Findings presented in this study provide useful information on the antihypertensive property of fruits, alongside some possible mechanisms. Hence, fruits could be considered a dietary regimen and functional food in alleviating hypertension.
本研究旨在探讨水果对 L-NAME 诱导的高血压大鼠血压、NO/cGMP 信号通路、血管紧张素转换酶和精氨酸酶活性以及氧化应激生物标志物的影响。
将 42 只 Wistar 大鼠分为 7 组。通过口服给予 40mg/kg 的 L-NAME 21 天诱导高血压。此后，用富含水果的饮食和西地那非枸橼酸盐对高血压大鼠进行 21 天治疗。测量血压并制备心脏匀浆进行生化分析。
结果表明，L-NAME 导致收缩压和舒张压、心率以及 ACE、精氨酸酶和 PDE-5 活性显著升高（<0.05），同时降低了 NO 和 HS 水平，并增加了氧化应激生物标志物。然而，富含水果的饮食和西地那非枸橼酸盐的治疗降低了血压，并调节了 ACE、精氨酸酶和 PDE-5 活性，改善了 NO 和 HS 水平以及抗氧化状态。
本研究提供了关于水果降压特性的有用信息，以及一些可能的机制。因此，水果可以被认为是一种饮食方案和功能性食品，可用于缓解高血压。
