Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.
Br J Radiol. 2020 Oct 1;93(1114):20200183. doi: 10.1259/bjr.20200183. Epub 2020 Aug 14.
The first hospital-based treatment facilities for particle therapy started operation about thirty years ago. Since then, the clinical experience with protons and carbon ions has grown continuously and more than 200,000 patients have been treated to date. The promising clinical results led to a rapidly increasing number of treatment facilities and many new facilities are planned or under construction all over the world. An inverted depth-dose profile combined with potential radiobiological advantages make charged particles a precious tool for the treatment of tumours that are particularly radioresistant or located nearby sensitive structures. A rising number of trials have already confirmed the benefits of particle therapy in selected clinical situations and further improvements in beam delivery, image guidance and treatment planning are expected. This review summarises some physical and biological characteristics of accelerated charged particles and gives some examples of their clinical application. Furthermore, challenges and future perspectives of particle therapy will be discussed.
大约三十年前，第一批基于医院的粒子治疗设施开始运营。自那时以来，质子和碳离子的临床经验不断增长，迄今为止已有超过 20 万名患者接受了治疗。有前途的临床结果导致治疗设施的数量迅速增加，目前世界各地正在规划或建设许多新设施。反深度剂量分布与潜在的放射生物学优势相结合，使带电粒子成为治疗特别耐辐射或靠近敏感结构的肿瘤的宝贵工具。越来越多的试验已经证实了粒子治疗在选定临床情况下的益处，并且预计在束流输送、图像引导和治疗计划方面会有进一步的改进。本文总结了加速带电粒子的一些物理和生物学特性，并举例说明了它们的临床应用。此外，还讨论了粒子治疗的挑战和未来展望。
