Soltanzadeh H, Wychulis A R, Sadr F, Bolanowski P J, Neville W E
Ann Surg. 1977 Jul;186(1):13-16. doi: 10.1097/00000658-197707000-00002.
Fourteen patients with aspergilloma (fungus ball) were reviewed. Hemoptysis was the major symptom (93%). Chest roentgenograms disclosed a "fungus ball" in every patient, and the mycelia of Aspergillus fumigatus were recovered from all resected specimens. One of three patients treated by pneumonectomy died post-operatively. A lobectomy was performed in ten patients, and segmental resection in one without mortality or significant morbidity. There has been no evidence of recurrence in a follow up of six months to ten years. On the basis of this experience and a review of the literature, excision of a solitary "fungus ball" is recommended when the diagnosis is made. Non-surgical therapy should be reserved for patients whose general medical status or pulmonary reserved prohibit resection.
对14例曲菌球患者进行了回顾性研究。咯血是主要症状(93%)。胸部X线片显示每位患者均有“曲菌球”,所有切除标本均培养出烟曲霉菌丝体。3例行肺切除术的患者中有1例术后死亡。10例行肺叶切除术,1例行肺段切除术,均无死亡或严重并发症。随访6个月至10年,无复发迹象。基于这一经验及文献复习,建议一旦确诊为孤立性“曲菌球”,应行手术切除。对于一般状况或肺储备功能不允许手术切除的患者,应采用非手术治疗。