Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Unidad de Investigación Médica en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, C.P. 06720, Ciudad de México, Mexico.
BMC Endocr Disord. 2020 Aug 14;20(1):124. doi: 10.1186/s12902-020-00603-7.
Modern imaging plays a central role in the care of obese patients, and there is an integral focus on its use and accessibility in individuals who have alterations of various in various organs. The objective in this study was to perform an echographic analysis of musculoskeletal system disorders, endothelial dysfunction and the left ventricle (LV) in obese rats.
Sprague Dawley rats (250 ± 5 g) were obtained and divided into two groups: the control (C) group was fed with a standard diet, and the obese (Ob) group was fed hyper caloric diet with a high fructose-fat content for 4 months. Body weight, cholesterol, triglycerides, glucose, inflammatory cytokines and adhesion molecules (ICAM-1, VCAM-1) were measured. Additionally, two-dimensional echocardiography, abdominal ultrasound and musculoskeletal system studies were performed in the lower extremities.
The body weight in the Ob group was increased compared to that in the control group, (p < 0.001); in addition, increased glucose, cholesterol and triglyceride concentrations (p < 0.05) as well as increased levels of the adhesion molecules ICAM-1 and, VCAM-1 (p < 0.01) were found in the Ob group vs the C group. On ultrasound, 75% of the Ob group presented fatty liver and distal joint abnormalities.
Obese rats exhibit endothelial dysfunction and musculoskeletal changes, also, fatty liver and articular cysts in the posterior region of the distal lower- extremity joints.
现代影像学在肥胖患者的治疗中起着核心作用，尤其关注其在各种器官改变的个体中的应用和可及性。本研究的目的是对肥胖大鼠的肌肉骨骼系统疾病、内皮功能障碍和左心室（LV）进行超声分析。
获得 Sprague Dawley 大鼠（250±5g），并分为两组：对照组（C）喂饲标准饮食，肥胖组（Ob）喂饲高果糖高脂肪高热量饮食 4 个月。测量体重、胆固醇、甘油三酯、葡萄糖、炎性细胞因子和黏附分子（ICAM-1、VCAM-1）。此外，还对下肢进行了二维超声心动图、腹部超声和肌肉骨骼系统研究。
Ob 组的体重比 C 组增加（p<0.001）；此外，Ob 组的葡萄糖、胆固醇和甘油三酯浓度升高（p<0.05），黏附分子 ICAM-1 和 VCAM-1 水平升高（p<0.01）。超声显示，75%的 Ob 组有脂肪肝和远侧关节异常。
肥胖大鼠表现出内皮功能障碍和肌肉骨骼变化，还表现出脂肪肝和远侧下肢关节后区的关节囊肿。
