Martin-DeLeon P A, Picciano S R
School of Life and Health Sciences, University of Delaware, Newark 19716.
Somat Cell Mol Genet. 1988 Mar;14(2):205-10. doi: 10.1007/BF01534405.
The use of a human cDNA probe and a Robertsonian translocation marker allowed us to localize the murine c-Ki-ras-2 oncogene to 6F-G at the telomere. Our finding provides support for the hypothesis that oncogenes have a preferred telomeric territory that is evolutionarily conserved. Given our physical mapping of c-Ki-ras-2 to 6F-G, the role of this oncogene in the genesis and/or maintenance of granulocytic leukemias can now be explored by correlating the oncogenic site to that of the structural rearrangement of chromosome 6 seen in the tumors.
使用人类cDNA探针和罗伯逊易位标记，我们能够将小鼠c-Ki-ras-2癌基因定位到端粒处的6F-G。我们的发现支持了这样一种假说，即癌基因具有进化上保守的优先端粒区域。鉴于我们将c-Ki-ras-2物理定位到6F-G，现在可以通过将致癌位点与肿瘤中观察到的6号染色体结构重排位点相关联，来探索该癌基因在粒细胞白血病发生和/或维持中的作用。
