Puri Vivek, Sharma Ameya, Kumar Pradeep, Singh Inderbir
Chitkara College of Pharmacy, Chitkara University, Punjab 140401, India.
Chitkara University School of Pharmacy, Chitkara University, Himachal Pradesh 174103, India.
Polymers (Basel). 2020 Aug 11;12(8):1803. doi: 10.3390/polym12081803.
Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers different thiolation methods and evaluation/characterization techniques have been discussed in detail. Reported literature on thiolated biopolymers with enhanced mechanical and mucoadhesive properties has been presented conspicuously in text as well as in tabular form. Patents filed by researchers on thiolated polymers have also been presented. In conclusion, thiolation is an easily reproducible and efficient method for customization of mucoadhesive and mechanical properties of biopolymers for drug delivery applications.
生物聚合物因其易于获取、经济、易于改性、无毒、可生物降解和生物相容性良好，而被广泛用于开发药物递送系统。硫醇化是一种充分报道的增强聚合物粘膜粘附性和机械性能的方法。在本综述文章中，详细讨论了用于生物聚合物改性的不同硫醇化方法以及评估/表征技术。具有增强机械性能和粘膜粘附性的硫醇化生物聚合物的相关文献已以文本和表格形式显著呈现。还介绍了研究人员提交的关于硫醇化聚合物的专利。总之，硫醇化是一种易于重现且高效的方法，可用于定制用于药物递送应用的生物聚合物的粘膜粘附性和机械性能。
