Piccirillo M, Taylor K J, Flye M W, Burns P N, True L D, Weltin G
Department of Diagnostic Imaging, Yale University School of Medicine, New Haven, CT 06510.
Ultrasound Med Biol. 1988;14(2):111-5. doi: 10.1016/0301-5629(88)90177-9.
A porcine model was devised to investigate Doppler waveforms in dysfunctional renal allografts. NIH miniature pigs served as allografts donors and recipients. Renal transplantation was effected into the recipient pelvis while the left normotopic kidney was subjected to warm ischemia in order to induce acute tubular necrosis (ATN). Doppler demonstration of allograft arterial occlusion in six animals was confirmed at surgery. Increased pulsatility of intrarenal arterial signals constituted evidence of vascular rejection in two animals. Biopsies confirmed the diagnosis in both cases. Histologic changes of ATN were identified in two native kidneys subjected to ischemia. No waveform or pulsatility alterations were observed in these animals. The porcine model provides for the investigation of allograft Doppler waveforms in a controlled setting with free access to biopsy and operative pathologic correlation.
设计了一种猪模型来研究功能失调的肾移植中的多普勒波形。美国国立卫生研究院小型猪作为同种异体移植供体和受体。将肾脏移植到受体盆腔，同时对左侧正常位置的肾脏进行热缺血以诱导急性肾小管坏死（ATN）。术中证实6只动物的同种异体移植动脉闭塞的多普勒表现。2只动物肾内动脉信号搏动性增加构成血管排斥的证据。活检在两种情况下均证实了诊断。在2个经受缺血的天然肾脏中发现了ATN的组织学变化。在这些动物中未观察到波形或搏动性改变。该猪模型可在可控环境中研究同种异体移植多普勒波形，便于进行活检和手术病理相关性研究。
