Department of Oncology, Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Department of Plastic Surgery, Xiangya Hospital of Central South University, Changsha, 410008, China.
Oncogene. 2020 Sep;39(38):6071-6084. doi: 10.1038/s41388-020-01421-w. Epub 2020 Aug 14.
The long non-coding RNA (LncRNA) abnormally expresses in several cancers including non-small cell lung cancer (NSCLC). To better understand the role of key lncRNA involving cancer progress, we conduct a comprehensive data mining on LINC00467 and determine its molecular mechanisms. We identified LINC00467 was the up-regulated lncRNA that common significantly differentially expressed in NSCLC and CRC tissues from GEO database. LINC00467 highly expressed in NSCLC tissues and associated with advanced clinical stages and poor outcome. Knockdown of LINC00467 inhibited cell growth and metastasis via regulating the Akt signaling pathway. Finally, we demonstrated that TDG mediated acetylation is the key factor controlling LINC00467 expression. In conclusion, LINC00467 promotes NSCLC progression via Akt signal pathway. The identified LINC00467 may serve as a valuable diagnostic and prognostic biomarker as well as a therapeutic target for NSCLC.
长链非编码 RNA（lncRNA）在多种癌症中异常表达，包括非小细胞肺癌（NSCLC）。为了更好地了解涉及癌症进展的关键 lncRNA 的作用，我们对 LINC00467 进行了全面的数据挖掘，并确定了其分子机制。我们发现 LINC00467 是在 GEO 数据库中 NSCLC 和 CRC 组织中常见的上调 lncRNA，差异表达显著。LINC00467 在 NSCLC 组织中高表达，并与晚期临床分期和不良预后相关。敲低 LINC00467 通过调节 Akt 信号通路抑制细胞生长和转移。最后，我们证明 TDG 介导的乙酰化是控制 LINC00467 表达的关键因素。总之，LINC00467 通过 Akt 信号通路促进 NSCLC 的进展。鉴定的 LINC00467 可能作为 NSCLC 的有价值的诊断和预后生物标志物以及治疗靶标。
