Wuya College of Innovation, Key Laboratory of Structure‑Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China.
Institute of Structural Pharmacology and TCM Chemical Biology, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China.
Int J Mol Med. 2023 Aug;52(2). doi: 10.3892/ijmm.2023.5271. Epub 2023 Jun 23.
Non‑small cell lung cancer (NSCLC) is one of the most common malignancies with a high morbidity and mortality rate. Long non‑coding RNAs (lncRNAs) have been reported to be closely associated with the occurrence and progression of NSCLC. In addition, lncRNAs have been documented to participate in the development of drug resistance and radiation sensitivity in patients with NSCLC. Due to their extensive functional characterization, high tissue specificity and sex specificity, lncRNAs have been proposed to be novel biomarkers and therapeutic targets for NSCLC. Therefore, in the current review, the functional classification of lncRNAs were presented, whilst the potential roles of lncRNAs in NSCLC were also summarized. Various physiological aspects, including proliferation, invasion and drug resistance, were all discussed. It is anticipated that the present review will provide a perspective on lncRNAs as potential diagnostic molecular biomarkers and therapeutic targets for NSCLC.
非小细胞肺癌（NSCLC）是最常见的恶性肿瘤之一，具有高发病率和死亡率。长链非编码 RNA（lncRNA）已被报道与 NSCLC 的发生和发展密切相关。此外，lncRNA 已被证明参与 NSCLC 患者的耐药性和辐射敏感性的发展。由于其广泛的功能特征、组织特异性和性别特异性，lncRNA 已被提议作为 NSCLC 的新型生物标志物和治疗靶点。因此，在本综述中，呈现了 lncRNA 的功能分类，同时总结了 lncRNA 在 NSCLC 中的潜在作用。讨论了包括增殖、侵袭和耐药性在内的各种生理方面。预计本综述将为 lncRNA 作为 NSCLC 的潜在诊断分子生物标志物和治疗靶点提供一个视角。
