Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Department of Health Informatics, Rutgers University School of Health Professions, Newark, NJ, USA.
J Vis. 2020 Aug 3;20(8):17. doi: 10.1167/jov.20.8.17.
This study was designed to identify the neural substrates activated during a phoria adaptation task using functional magnetic resonance imaging (MRI) in young adults with normal binocular vision and to test the repeatability of the fMRI measurements for this protocol. The phoria adaptation task consisted of a block protocol of 90 seconds of near visual crossed fixation followed by 90 seconds of far visual uncrossed fixation, repeated three times; the data were collected during two different experimental sessions. Results showed that the oculomotor vermis, cuneus, and primary visual cortex had the greatest functional activity within the regions of interest studied when stimulated by the phoria adaptation task. The oculomotor vermis functional activity had an intraclass correlation coefficient (ICC) of 0.3, whereas the bilateral cuneus and primary visual cortex had good ICC results of greater than 0.6. These results suggest that the sustained visual fixation task described within this study reliably activates the neural substrates of phoria adaptation. This protocol establishes a methodology that can be used in future longitudinal studies investigating therapeutic interventions that may modify phoria adaptation.
本研究旨在使用功能磁共振成像（fMRI）技术，在具有正常双眼视觉的年轻成年人中，确定在斜视适应任务期间激活的神经基质，并测试该方案的 fMRI 测量的可重复性。斜视适应任务包括近视觉交叉固定 90 秒，然后远视觉不交叉固定 90 秒，重复三次；数据在两个不同的实验中采集。结果表明，在受斜视适应任务刺激时，眼动小脑蚓部、楔叶和初级视觉皮层的功能活性最大。眼动小脑蚓部的功能活性具有 0.3 的组内相关系数（ICC），而双侧楔叶和初级视觉皮层具有大于 0.6 的良好 ICC 结果。这些结果表明，本研究中描述的持续视觉固定任务可靠地激活了斜视适应的神经基质。该方案建立了一种可以在未来的纵向研究中使用的方法，该研究可以研究可能改变斜视适应的治疗干预措施。
