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免疫疗法相关性结肠炎的管理:COVID-19 时代的特殊考虑。

Management of immunotherapy colitis: Special considerations in the COVID-19 era.

机构信息

Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

出版信息

Cancer. 2020 Nov 1;126(21):4630-4633. doi: 10.1002/cncr.33125. Epub 2020 Aug 14.

DOI:10.1002/cncr.33125
PMID:32797685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7461305/
Abstract

The evaluation and management of patients with cancer with suspected immune checkpoint inhibitor (ICI) colitis have distinct challenges within the setting of the coronavirus disease 2019 (COVID‐19) pandemic. The approach to the treatment of patients with ICI colitis requires consideration of the risks and benefits of individual immunosuppressive medications and varies based on the presence of a concurrent COVID‐19 infection.

摘要

在 2019 冠状病毒病(COVID-19)大流行背景下,疑似免疫检查点抑制剂(ICI)结肠炎的癌症患者的评估和管理具有独特的挑战。ICI 结肠炎患者的治疗方法需要考虑个体免疫抑制药物的风险和获益,并根据是否存在同时感染 COVID-19 而有所不同。

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本文引用的文献

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Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19.美国传染病学会关于新冠病毒病诊断的指南
Clin Infect Dis. 2020 Jun 16. doi: 10.1093/cid/ciaa760.
2
Impact of Anti-Tumor Necrosis Factor and Thiopurine Medications on the Development of COVID-19 in Patients With Inflammatory Bowel Disease: A Nationwide Veterans Administration Cohort Study.抗肿瘤坏死因子和硫嘌呤类药物对炎症性肠病患者感染新型冠状病毒肺炎的影响:一项全国退伍军人事务部队列研究
Gastroenterology. 2020 Oct;159(4):1545-1546.e1. doi: 10.1053/j.gastro.2020.05.065. Epub 2020 May 29.
3
Pediatric Crohn Disease and Multisystem Inflammatory Syndrome in Children (MIS-C) and COVID-19 Treated With Infliximab.儿童克罗恩病和儿童多系统炎症综合征(MIS-C)与 COVID-19 采用英夫利昔单抗治疗。
J Pediatr Gastroenterol Nutr. 2020 Aug;71(2):153-155. doi: 10.1097/MPG.0000000000002809.
4
Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry.皮质类固醇,而不是 TNF 拮抗剂,与炎症性肠病患者 COVID-19 不良结局相关:来自国际登记处的结果。
Gastroenterology. 2020 Aug;159(2):481-491.e3. doi: 10.1053/j.gastro.2020.05.032. Epub 2020 May 18.
5
Abdominal Imaging Findings in COVID-19: Preliminary Observations.COVID-19 的腹部影像学表现:初步观察。
Radiology. 2020 Oct;297(1):E207-E215. doi: 10.1148/radiol.2020201908. Epub 2020 May 11.
6
AGA Clinical Practice Update on Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: Expert Commentary.美国胃肠病学会关于2019冠状病毒病大流行期间炎症性肠病管理的临床实践更新:专家评论
Gastroenterology. 2020 Jul;159(1):350-357. doi: 10.1053/j.gastro.2020.04.012. Epub 2020 Apr 10.
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