Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China; State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), Shenzhen 518057, China.
Phytomedicine. 2021 May;85:153297. doi: 10.1016/j.phymed.2020.153297. Epub 2020 Aug 5.
Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout China and in other countries since the end of 2019. The World Health Organization (WHO) has declared that the epidemic is a public health emergency of international concerns. The timely and appropriate measures for treating COVID-19 in China, which are inseparable from the contribution of traditional Chinese medicine (TCM), have won much praise of the world.
This review aimed to summarize and discuss the essential role of TCM in protecting tissues from injuries associated with COVID-19, and accordingly to clarify the possible action mechanisms of TCM from the perspectives of anti-inflammatory, antioxidant and anti-apoptotic effects.
Electronic databases such as Pubmed, ResearchGate, Science Direct, Web of Science, medRixv and Wiley were used to search scientific literatures.
The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhizaSalvia miltiorrhiza, and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis.
TCM could protect COVID-19 patients from tissue injuries, a protection that might be, at least partially, attributed to the anti-inflammatory, antioxidant and anti-apoptotic effects of the TCM under investigation. This review provides evidence and support for clinical treatment and novel drug research using TCM.
自 2019 年底以来，由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）感染引起的 2019 年冠状病毒病（COVID-19）在中国和其他国家迅速蔓延。世界卫生组织（WHO）已宣布该疫情为国际关注的突发公共卫生事件。中国对 COVID-19 的及时、恰当治疗措施，离不开中医药的贡献，这赢得了世界的赞誉。
本综述旨在总结和讨论中医药在保护组织免受 COVID-19 相关损伤方面的重要作用，并从抗炎、抗氧化和抗细胞凋亡作用的角度阐明中医药的可能作用机制。
使用 Pubmed、ResearchGate、Science Direct、Web of Science、medRixv 和 Wiley 等电子数据库搜索科学文献。
本综述发现，临床上用于治疗 COVID-19 引起的器官损伤的常用中草药，如黄芩、丹参和人参，可能作用于涉及炎症、氧化应激和细胞凋亡的多种信号通路。
中医药可保护 COVID-19 患者免受组织损伤，这种保护作用至少部分归因于所研究的中医药的抗炎、抗氧化和抗细胞凋亡作用。本综述为使用中医药进行临床治疗和新药研究提供了证据和支持。
