Zhao Kangning, Zhang Jinlong, Zhou Lin, Sun Zhen
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
The Second Gastroenterology Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Pharmacol. 2024 Nov 25;15:1483785. doi: 10.3389/fphar.2024.1483785. eCollection 2024.
has been used for the treatment of digestive system disorders for thousands of years in China and other regions. Modern research have revealed its therapeutic efforts in digestive system tumors. Thus, to review the updated progress of and its main flavonoids in the treatment of digestive system tumors in the past 10 years, this article summarized the therapeutic effect and molecular mechanisms of and its 5 flavonoids on tumors in oral cavity, esophagus, stomach, colon, liver, pancreas by inhibiting tumor cell proliferation, inducing autophagy, stimulating immune response, and increasing drug sensitivity. In conclusion, and its flavonoids could be applied to treat digestive system tumors with different type of methods.
在中国和其他地区，它已被用于治疗消化系统疾病数千年。现代研究揭示了其在消化系统肿瘤中的治疗作用。因此，为了回顾其及其主要黄酮类化合物在过去10年中治疗消化系统肿瘤的最新进展，本文总结了其及其5种黄酮类化合物通过抑制肿瘤细胞增殖、诱导自噬、刺激免疫反应和增加药物敏感性对口腔、食管、胃、结肠、肝脏、胰腺肿瘤的治疗效果及分子机制。总之，其及其黄酮类化合物可通过不同方法应用于治疗消化系统肿瘤。
