Cameron N, Mitchell J, Meyer D, Moodie A, Bowie M D, Mann M D, Hansen J D
Department of Anatomy, Medical School, University of the Witwatersrand, Johannesburg.
Ann Hum Biol. 1988 Jan-Feb;15(1):65-75. doi: 10.1080/03014468800009471.
This report describes the secondary sexual development of 45 'Cape Coloured' female ex-kwashiorkor patients and 43 female controls. All patients were originally seen between five months and four years four months of age, treated and then followed up for 15 years after discharge. Age at menarche was available on 42 ex-patients and 33 controls, and age at peak height velocity (PHV) was available for 30 ex-patients and 15 controls. Maximum likelihood estimates of the mean age at entry to each pubertal stage were made, age at menarche was obtained directly from the subject records and age at PHV was obtained by fitting a non-linear growth function to the data for each subject. All subjects passed through the sequence of pubertal events in the normal order, i.e., no reversals were observed. Ex-patients were generally delayed in relation to controls but there were no significant differences for ages at entry to any of the pubertal stages. The subjects were combined for comparison to equivalent data on British girls. The South African girls were significantly delayed in the development of pubic hair and menarche but showed no significant differences for age at entry or duration of breast development and PHV. It is suggested that lack of delay in breast development may have selective advantages to females living in situations of chronic malnutrition.
本报告描述了45名曾患夸休可尔症的“开普有色人种”女性患者和43名女性对照者的第二性征发育情况。所有患者最初就诊时年龄在5个月至4岁4个月之间，接受治疗后出院并随访15年。42名 former patients 和33名对照者有月经初潮年龄数据，30名 former patients 和15名对照者有身高增长速度峰值（PHV）年龄数据。对进入每个青春期阶段的平均年龄进行了最大似然估计，月经初潮年龄直接从受试者记录中获取，PHV年龄通过对每个受试者的数据拟合非线性生长函数获得。所有受试者均按正常顺序经历青春期事件序列，即未观察到逆转情况。former patients 相对于对照者通常发育延迟，但进入任何青春期阶段的年龄无显著差异。将这些受试者的数据与英国女孩的等效数据合并进行比较。南非女孩在阴毛发育和月经初潮方面明显延迟，但在乳房发育开始年龄、乳房发育持续时间和PHV方面无显著差异。有人认为，乳房发育未延迟可能对生活在慢性营养不良环境中的女性具有选择性优势。
