Cameron N, Mitchell J, Meyer D, Moodie A, Bowie M D, Mann M D, Hansen J D
Department of Anatomy, University of Witwatersrand, Johannesburg, Cape Town.
Ann Hum Biol. 1990 May-Jun;17(3):217-28. doi: 10.1080/03014469000000982.
This report describes the secondary sexual development of 78 Cape Coloured male ex-kwashiorkor patients and 53 male controls. All patients were originally seen between 5 months and 4 years 4 months of age, treated and then followed up for 15 years after discharge. Age at peak height velocity (PHV) was available for 23 ex-patients and 15 controls. Maximum likelihood estimates of the mean age at entry to each pubertal stage were made and age at PHV was obtained by fitting a non-linear growth function to the data for each subject with appropriate serial height records. No significant differences were observed between ex-patients and controls for either the sequence of pubertal events or for the age of entry to each stage. When compared to a sample of normal British boys the Cape Coloured sample exhibited significant delay for ages at entry to all pubertal stages with differences ranging from 0.84 years for PH2 to 1.94 years for PH5. It is suggested that adrenal androgens play a major role in delaying secondary sexual development during chronic malnutrition and that the anterior pituitary's response to such conditions is to selectively delay pubertal status.
本报告描述了78名开普有色人种前夸休可尔症男性患者和53名男性对照者的第二性征发育情况。所有患者最初就诊时年龄在5个月至4岁4个月之间，接受治疗后出院并随访15年。23名 former patients 和15名对照者有身高生长高峰速度（PHV）时的年龄数据。通过对每个有适当连续身高记录的受试者的数据拟合非线性生长函数，得出进入每个青春期阶段的平均年龄的最大似然估计值，并获得PHV时的年龄。former patients 和对照者在青春期事件顺序或进入每个阶段的年龄方面均未观察到显著差异。与英国正常男孩样本相比，开普有色人种样本在进入所有青春期阶段的年龄方面均出现显著延迟，差异范围从PH2阶段的0.84岁到PH5阶段的1.94岁。研究表明，在慢性营养不良期间，肾上腺雄激素在延迟第二性征发育中起主要作用，并且垂体前叶对这种情况的反应是选择性地延迟青春期状态。
