万古霉素单独及与头孢他啶联合应用于健康志愿者的药代动力学及血清杀菌活性
Pharmacokinetics and serum bactericidal activity of vancomycin alone and in combination with ceftazidime in healthy volunteers.
作者信息
Boeckh M, Lode H, Borner K, Höffken G, Wagner J, Koeppe P
机构信息
Medical Department, Klinikum Steglitz, Freie Universität Berlin, Federal Republic of Germany.
出版信息
Antimicrob Agents Chemother. 1988 Jan;32(1):92-5. doi: 10.1128/AAC.32.1.92.
Abstract
The pharmacokinetics and serum bactericidal activity of vancomycin alone and in combination with ceftazidime were investigated in 10 healthy volunteers. The pharmacokinetic parameters showed no significant differences (P less than 0.05) between single and combined administration. No antagonistic effects were observed in serum bactericidal activity with the combination against 20 gram-positive and 20 gram-negative locally isolated bacteria. A titer of greater than or equal to 1:8 was generated by the combination against all test strains except enterococci. Seven of ten volunteers developed a typical "red man's syndrome" during the administration of 1.0 g of vancomycin.
摘要
在10名健康志愿者中研究了万古霉素单独使用及与头孢他啶联合使用时的药代动力学和血清杀菌活性。药代动力学参数显示单次给药和联合给药之间无显著差异（P小于0.05）。联合用药对20株革兰氏阳性菌和20株革兰氏阴性本地分离菌的血清杀菌活性未观察到拮抗作用。联合用药对除肠球菌外的所有测试菌株产生的效价均大于或等于1:8。10名志愿者中有7名在静脉注射1.0 g万古霉素过程中出现了典型的“红人综合征”。
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